{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:06Z","timestamp":1787761926923,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In the recent years, an increasing number of peri\u2010implant medication\u2010related osteonecrosis of the jaw (PI\u2010MRONJ) have been reported in literature, both in oncologic and osteoporotic patients. The aim of this study is to describe 19 cases of patients previously diagnosed as affected by peri\u2010implantitis, who were treated for PI\u2010MRONJ, with consideration on clinical and histopathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients included were affected by postmenopausal osteoporosis and were administered with different antiresorptive drugs. Due to the presence of clinical and radiological signs of peri\u2010implantitis not healed after non\u2010surgical periodontal treatment, they were referred to the Complex Operating Unit of Odontostomatology of the University of Bari. Then, after a drug holiday of at least 3\u00a0months and cycles of antibiotics, and after other cycles of periodontal treatment, patients underwent the surgical removal of implant fixtures and surrounding bone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although the previous diagnosis of peri\u2010implantitis, the histopathological analysis with both conventional and confocal laser scanner microscopy confirmed the diagnosis of peri\u2010implantitis\u2010like MRONJ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peri\u2010implantitis not healed after conventional treatment in patients at risk on MRONJ occurrence should be considered as peri\u2010implantitis\u2010like PI\u2010MRONJ and treated as required in order to get complete healing of the pathological condition, thus avoiding delay in the diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13873","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T12:57:20Z","timestamp":1618232240000},"page":"1603-1609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Peri\u2010implantitis\u2010like medication\u2010related osteonecrosis of the jaw: Clinical considerations and histological evaluation with confocal laser scanning microscope"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-6292","authenticated-orcid":false,"given":"Angela","family":"Tempesta","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Medicine Complex Operating Unit of Odontostomatology Aldo Moro University of Bari  Bari 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