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The scientific quality of the evidence was rated according to NIH Quality Assessment Tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>4,051 articles were found, 59 were reviewed in full text, and 29 studies were included. With the exception of hereditary coagulopathies, which were identified as potential risk factors in five studies, suggestions concerning the aetiology varied widely. No gold standard diagnostic mean could be identified. Treatment was most often performed by surgical curettage of the affected bone. Surgical treatment outcomes were equally varied: significant facial pain remission was reported in 66%\u2013100% for periods varying between 2\u00a0months to 18\u00a0years, whereas no or little relief and recurrences were reported in up to \u2153 of cases. All studies were observational in their design. All investigations were rated as poor quality because of high risk of bias and non\u2010transparent reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence concerning the aetiology, diagnosis and treatment of NICO is poor. Prospective diagnostic and therapeutic studies are needed before the usefulness of invasive therapeutic procedures can be evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13886","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T03:55:40Z","timestamp":1619236540000},"page":"1448-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuralgia\u2010inducing cavitational osteonecrosis \u2013 A systematic review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-4880","authenticated-orcid":false,"given":"Caroline","family":"Sekundo","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Schleswig \u2010 Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Schliephake","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Goettingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Al\u2010Nawas","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"R\u00fcckschlo\u00df","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Moratin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Ristow","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2015.2.20140501"},{"key":"e_1_2_10_3_1","unstructured":"American Association of Endodontics (AAE): AAE Position Statement. 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