{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:27:51Z","timestamp":1787495271009,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Periodontitis disease infection initiates host immune response, and alveolar bone damage is a hallmark of periodontitis. Bone damage occurs due to changes in osteoclast activity in response to local inflammation. Nuclear factor \u03baB (NF\u2010\u03baB) signaling is essential for inflammatory responses and plays a pivotal role in osteoclast formation and activation. Tripartite motif 14 (\n                      <jats:italic>Trim14<\/jats:italic>\n                      ) is a crucial regulator of the noncanonical NF\u2010\u03baB signaling. Here, we investigated the role of\n                      <jats:italic>Trim14<\/jats:italic>\n                      in chronic periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The development of immune cells and osteoclast formation was evaluated with flow cytometry, qRT\u2010PCR, and histochemical staining. Proinflammatory cytokines were checked by ELISA and qRT\u2010PCR. Protein expression was determined by immunoblotting. Also, the cemento\u2010enamel junction\u2013alveolar bone crest distance was evaluated in the mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Development of innate and adaptive cells was not impaired from the deletion of\n                      <jats:italic>Trim14<\/jats:italic>\n                      . However, the genetic loss of\n                      <jats:italic>Trim14<\/jats:italic>\n                      remarkably suppressed RANKL\u2010induced osteoclastogenesis, without affecting TLR\u2010induced proinflammatory cytokines except for\n                      <jats:italic>Il\u201023a<\/jats:italic>\n                      expression. The\n                      <jats:italic>Trim14<\/jats:italic>\n                      deletion also suppressed the activation of noncanonical NF\u2010\u03baB signaling by targeting p100\/p52. Importantly, the deletion of\n                      <jats:italic>NIK<\/jats:italic>\n                      diminished the effects of\n                      <jats:italic>Trim14<\/jats:italic>\n                      on the inflammatory responses in vivo on chronic periodontitis responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TRIM14 may be a positive regulator to promote osteoclastogenesis and proinflammatory cytokine secretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13888","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:57:13Z","timestamp":1619445433000},"page":"1958-1967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trim14 promotes osteoclastogenesis and noncanonical NF\u2010\u03baB activation by targeting p100\/p52 in chronic periodontitis"],"prefix":"10.1111","volume":"28","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dental Clinic Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuya","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-7234","authenticated-orcid":false,"given":"Jiankun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"issue":"10","key":"e_1_2_9_2_1","first-page":"761","article-title":"Systemic diseases among patients with and without alveolar bone loss","volume":"37","author":"Al\u2010Emadi A.","year":"2006","journal-title":"Quintessence International"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23763"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513500306"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1885"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2165"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2015.30.1.35"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2009.05315.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.08.025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901261"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01395"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.503"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEC.2017.0078"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12286"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540500137669"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080183"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2007.01172.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359\u20106101(02)00026\u20106"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010065X.2012.01100.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374\u2010018\u20100137\u20101"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/615486"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz040"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2018.09.004"},{"issue":"3","key":"e_1_2_9_26_1","first-page":"161","article-title":"The 4th National Oral Health Survey in the mainland of China: Background and methodology","volume":"21","author":"Lu H. 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