{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T16:03:06Z","timestamp":1788624186625,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effect of zoledronic acid (ZA) on human umbilical vein endothelial cells (HUVECs) attached to different surfaces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of three groups were evaluated in this study: sandblasting and acid etching (SLA) + HUVECs; mechanically polished (MP) + HUVECs; and plastic cell culture plates + HUVECs. Scanning electron microscopy, energy\u2010dispersive X\u2010ray spectroscopy, surface roughness and water contact angle were tested for titanium surface characterisation. ZA was added at different concentrations (0, 1, 10, 50 and 100\u00a0\u03bcM). Cell adhesion, proliferation, viability, apoptosis and gene expression were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mechanically polished and SLA surfaces showed negative effects on cell adhesion and proliferation and promoted cell apoptosis with 100\u00a0\u03bcM ZA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). The highest expression of intercellular adhesion molecule\u20101 (ICAM\u20101) and angiopoietin\u20101 was found on SLA surfaces (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). The lowest expression of platelet\u2010endothelial cell adhesion molecule\u20101 and ICAM\u20101 was found on MP surfaces (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). A significant decrease in von Willebrand factor was detected on MP and SLA surfaces (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Zoledronic acid has an anti\u2010angiogenic effect on HUVECs attached to titanium implants, while the SLA surface might stimulate HUVECs to express angiogenic and adhesive factor genes despite ZA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13890","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:58:04Z","timestamp":1619582284000},"page":"1968-1978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Titanium implant alters the effect of zoledronic acid on the behaviour of endothelial cells"],"prefix":"10.1111","volume":"28","author":[{"given":"Yi","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruogu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-3598","authenticated-orcid":false,"given":"Xiaolin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32539"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010017\u20102167\u20102"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.037"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID\u2010JOI\u2010D\u201011\u201000234"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010018\u20100474\u20104"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3507"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/009127002762491316"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12842"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.540387"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19\u20100213"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.585156"},{"issue":"10","key":"e_1_2_8_14_1","first-page":"475","article-title":"Adverse effects of bisphosphonates: Current issues","volume":"5","author":"Diel I. 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