{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:05:25Z","timestamp":1782453925573,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare manual and powered tooth brushing (MT and PT) with respect to patient compliance to brushing frequency advice, plaque removal and severity of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT) after high\u2010dose chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; methods<\/jats:title>\n                    <jats:p>\n                      A randomized controlled trial was conducted. Forty\u2010six patients scheduled to receive myeloablative conditioning regimen before autologous HSCT were included and randomly assigned to control (MT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a023) or test (PT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a023) groups. Starting at day 1 (day of hospital admission for HSCT), brushing frequency (patient recorded diary), plaque scores (Plaque Control Index) and oral mucositis (Oral Mucositis Nursing Index) were recorded daily. Data for days 1 to 17 were analysed using regression analysis and general linear models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Few patients maintained 4 times per day brushing, but most brushed at least 2 times per day throughout the study. In PT, overall plaque scores were lower by 6.98% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006) as compared to MT. No differences were seen in OM scores between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.968). A small but significant positive correlation was found between plaque scores and OM severity:\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0.15 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Powered tooth brushing resulted in lower plaque scores, but was not associated with reduced OM severity. Individual plaque scores were positively related to OM severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13899","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T03:21:21Z","timestamp":1620530481000},"page":"1987-1994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A randomized controlled trial of manual versus powered tooth brushing during haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"28","author":[{"given":"Carin M.J.","family":"Potting","sequence":"first","affiliation":[{"name":"Department of Haematology, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-3705","authenticated-orcid":false,"given":"Stephanie J.M.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"},{"name":"Department of Dentistry, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Helene","family":"Kurstjens","sequence":"additional","affiliation":[{"name":"Department of Oral Hygiene HAN university of applied sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewald M.","family":"Bronkhorst","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renske Z.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.A.","family":"Blijlevens","sequence":"additional","affiliation":[{"name":"Department of Haematology, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-7554","authenticated-orcid":false,"given":"Marie\u2010Charlotte D.N.J.M.","family":"Huysmans","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Radboudumc Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"100","article-title":"An effective method of personal oral hygiene; part II","volume":"106","author":"Bass C. 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