{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:51:27Z","timestamp":1778622687473,"version":"3.51.4"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Survival rate for oral tongue squamous cell carcinoma (OTSCC) is still poor and, despite Tumor\u2013Node\u2013Metastasis staging system has been recently updated, patients included under the same stage still show difference in prognosis. Perineural invasion (PNI) emerged to be an indicator of tumor aggressive behavior and unfortunate events. In this study, we investigate the clinic and prognostic value of PNI in a cohort of OTSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>About 200 patients with OTSCC were retrospectively evaluated the presence of PNI. PNI was furtherly descripted as uni\u2010\/multifocal and as intra\u2010\/peritumoral. Disease\u2010Specific and Relapse\u2010Free Survival (DSS; RFS) were estimated; moreover, we included PNI in the current AJCC 8th Staging System, improving the prognostication model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Perineural invasion was found in 40.5% of patients. Intratumoral PNI predicted patients at high risk of being diagnosed with lymph\u2013node metastasis. Tumors with positive PNI reported a worse DSS (Hazard Ratio=1.878,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0=\u00a00.008). Moreover, patients exhibiting both multifocal intra\u2010 and peritumoral PNI reported poorest DSS (Hazard Ratio\u00a0=\u00a02.409,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0=\u00a00.010). Patients were reclassified in a new staging system in case of multifocal PNI, providing better stratification capacity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perineural invasion might serve as an additional prognostic factor in OTSCC, and by integrating PNI in the staging system, further improvements in prognostication might be reached.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13900","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T03:21:46Z","timestamp":1620530506000},"page":"411-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Pattern and localization of perineural invasion predict poor survival in oral tongue carcinoma"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5921","authenticated-orcid":false,"given":"Vito Carlo Alberto","family":"Caponio","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-4414","authenticated-orcid":false,"given":"Giuseppe","family":"Troiano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrezia","family":"Togni","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences Marche Polytechnic University  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khrystyna","family":"Zhurakivska","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-3354","authenticated-orcid":false,"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences Marche Polytechnic University  Ancona Italy"},{"name":"Dentistry Clinic National Institute of Health and Science of Aging IRCCS INRCA  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Laino","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Dental Specialties University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Rubini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Public Health Marche Polytechnic University  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-4893","authenticated-orcid":false,"given":"Lorenzo","family":"Lo Muzio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-3752","authenticated-orcid":false,"given":"Marco","family":"Mascitti","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences Marche Polytechnic University  Ancona 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