{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:16:46Z","timestamp":1780377406721,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108013"],"award-info":[{"award-number":["81920108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001071"],"award-info":[{"award-number":["82001071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Incisors tubed prosthesis with bilateral anterior elevation (BAE) relation had been reported to stimulate the proliferative response in the mandibular condylar cartilage of mice, thus the prosthetic occlusion elevation had been proposed to treat cartilage degeneration. Currently, we aimed to detect the long\u2010term effect of BAE on temporomandibular joints (TMJs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Twelve 6\u2010week\u2010old female mice were assigned to age\u2010matched control and BAE groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06). Micro\u2010CT images and the macro\u2010 and micro\u2010morphology of the mandibular condyles were analyzed at 29\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the age\u2010matched controls, in BAE group, there were loss of subchondral cortical bone and heavy loss of the subchondral trabecular bone at the superior sites of the TMJ condyles, but hyperostosis at the inferior sites as revealed by micro\u2010CT images and histological slices. In BAE group, cartilage thickness and matrix area were increased with upregulated expression of type II, type X collagen, and Ki67, but the expression of cleaved caspase\u20103 was downregulated (all,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to cartilage thickening, long\u2010term BAE induces loss of the subchondral cortical bone and heavy loss of the underneath subchondral trabecular bone, but hyperostosis further underneath. Using BAE as a treatment remains double\u2010edged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13914","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T11:06:59Z","timestamp":1620817619000},"page":"1911-1920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term effect of bilateral anterior elevation of occlusion on the temporomandibular joints"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuejiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"},{"name":"School of Stomatology Jiamusi University  Jiamusi, Heilongjiang P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Xu","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"},{"name":"School of Stomatology Jiamusi University  Jiamusi, Heilongjiang P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-307X","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiguang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology Jiamusi University  Jiamusi, Heilongjiang P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-385X","authenticated-orcid":false,"given":"Meiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of 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