{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:48Z","timestamp":1772160828692,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771126"],"award-info":[{"award-number":["81771126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was designed to identify the role of circRNAs in tongue squamous cell carcinoma (TSCC) and discover novel circRNAs as potential diagnostic or therapeutic targets for TSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The circRNA expression profiles in TSCC were evaluated by high\u2010throughput sequencing in 6 TSCC patients. Our data showed that 69 circRNAs were downregulated and 208 were upregulated significantly (fold change \u22652.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). GO and KEGG analysis demonstrated that the parental genes of differentially expressed circRNAs were potentially implicated in TSCC pathogenesis. After bioinformatics analysis, 4 circRNAs (hsa_circ_0005035, hsa_circ_0002360, hsa_circ_0066251, and hsa_circ_0003161) were selected and successfully validated by quantitative reverse\u2010transcription polymerase chain reaction (qRT\u2010PCR) in 40 patients and 3 TSCC cell lines. The establishment and analysis of the circRNA\u2010miRNA\u2010mRNA network revealed the potential function and mechanism of these candidate circRNAs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study provided a comprehensive circRNAs expression profile of TSCC by RNA\u2010seq and discovered 4 novel circRNAs with potential great diagnostic and therapeutic value. These findings provide new insights into the development of potential biomarkers and targets for TSCC treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13933","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T08:49:40Z","timestamp":1622537380000},"page":"458-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Zexi","family":"Chen","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Jie","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zailing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Fujian Provincial Governmental Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Stomatology &amp; Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology Fujian Medical University  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