{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:12:01Z","timestamp":1781921521904,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Tongue squamous cell carcinoma (TSCC) is the most common malignancy in oral cancer. Long noncoding RNAs (lncRNAs) are important regulators in cancer biology. In our present study, we investigated a novel lncRNA IGF\u2010like family member 2 antisense RNA 1 (IGFL2\u2010AS1) in TSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RT\u2010qPCR analyzed IGFL2\u2010AS1 expression in TSCC cells. Functional assays assessed the impact of IGFL2\u2010AS1 on TSCC cell proliferation, migration, and invasion. Western blot analyzed the protein levels of EMT\u2010related markers. Mechanism assays analyzed the regulatory mechanism of IGFL2\u2010AS1 in TSCC cells. In\u2010vivo experiments were conducted to prove the role of IGFL2\u2010AS1 in TSCC progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IGFL2\u2010AS1 was significantly up\u2010regulated in TSCC cells and tissues, and IGFL2\u2010AS1 knockdown inhibited cell proliferation, migration, invasion and EMT in TSCC. Moreover, IGFL2\u2010AS1 functioned as a competing endogenous RNA (ceRNA) to sponge miR\u20101224\u20105p and thereby modulated SATB homeobox 1 (SATB1) expression. Additionally, SATB1 activated the Wnt\/\u03b2\u2010catenin signaling pathway in TSCC cells and IGFL2\u2010AS1 regulated the Wnt\/\u03b2\u2010catenin signaling pathway and TSCC progression via elevating SATB1 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data revealed that IGFL2\u2010AS1 played a cancer promoting role in TSCC and may aid in exploring a brand new biomarker that might contribute to TSCC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13935","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T07:48:17Z","timestamp":1622792897000},"page":"469-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["IGFL2\u2010AS1 facilitates tongue squamous cell carcinoma progression via Wnt\/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-3975","authenticated-orcid":false,"given":"Ruimin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics the First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an 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