{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:36Z","timestamp":1790030076228,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To survey the frequency and pattern of family history for non\u2010syndromic orofacial clefts (NSOFC). Initial hypothesis: more complex forms have a higher frequency of positive family history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective study was carried with 2,668 subjects with three different types of clefts (CL Group (cleft lip), CLP Group (cleft lip and palate), and CP group (cleft palate)); family history information was collected. The Chi\u2010square (X<jats:sup>2<\/jats:sup>) and Z\u2010test were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A positive family history was found in 31% of the sample. The CLP Group had highest percentage and highest proportion of affected relatives, being these factors statistically significant when compared to the CP Group. Comparisons between the CLP Male and CL Male with CP Male were statistically significant. First\u2010degree kinship was the most frequently found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The initial hypothesis was confirmed, subjects with CLP had the highest percentage of positive family history, the highest proportion of affected relatives and had more affected relatives in comparison with CP. It is more common to find affected relatives in the CLP Male and CL Male groups when compared with CP Male. CLP and CP groups present a pattern of occurrence of the type of cleft in the family.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13942","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T11:49:57Z","timestamp":1624103397000},"page":"2194-2203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Family history in non\u2010syndromic orofacial clefts: Is there a pattern?"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-4243","authenticated-orcid":false,"given":"Carolina Maia","family":"Silva","sequence":"first","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of Sao Paulo (Post\u2010Graduation Program in Rehabilitation Sciences\u2013HRAC\/USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-8198","authenticated-orcid":false,"given":"Maria Carolina de Moraes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of Sao Paulo (Post\u2010Graduation Program in Rehabilitation Sciences\u2013HRAC\/USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-2248","authenticated-orcid":false,"given":"Tha\u00eds Bernardes de","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of Sao Paulo (Post\u2010Graduation Program in Rehabilitation Sciences\u2013HRAC\/USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-0334","authenticated-orcid":false,"given":"Lucimara Teixeira das","family":"Neves","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of Sao Paulo (Post\u2010Graduation Program in Rehabilitation Sciences\u2013HRAC\/USP)  Bauru Brazil"},{"name":"Bauru School of Dentistry University of Sao Paulo (Department of Biological Science \u2013 FOB\/USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"78","key":"e_1_2_9_2_1","first-page":"7","article-title":"Common mutations of the methylenetetrahydrofolate reductase (MTHFR) gene in non\u2010syndromic cleft lips and palates children in North\u2010West of Iran","volume":"27","author":"Abdollahi\u2010Fakhim S.","year":"2015","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0120\u201041572011000300010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23221"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.08.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010015\u20100328\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u2010775720140517"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23417"},{"key":"e_1_2_9_10_1","first-page":"266","volume-title":"Inheritance of Harelip And Cleft Palate: Contribution to The Elucidation of Etiology of The Congenital Clefts of The Face","author":"Fogh\u2010Andersen P.","year":"1942"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1597\/11\u2010069"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000150783"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1678\u201077572012000100003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2016.56"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.069385"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010017\u20102102\u20106"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806\u201083242009000100006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31381"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010016\u20101116\u20104"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.01.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010020\u201000522\u20100"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.07.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.05.006"},{"key":"e_1_2_9_24_1","first-page":"342","article-title":"Abnormal morphology of the soft palate. 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