{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:53Z","timestamp":1790281793150,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2018J01819"],"award-info":[{"award-number":["2018J01819"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771126"],"award-info":[{"award-number":["81771126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2020QH2046"],"award-info":[{"award-number":["2020QH2046"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The treatment of patients with primary Sj\u00f6gren's syndrome is a clinical challenge. Gene expression profile analysis and comprehensive network methods for complex diseases can provide insight into molecular characteristics in the clinical context.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n We downloaded gene expression datasets from the Gene Expression Omnibus (GEO) database. We screened differentially expressed genes (DEG) between the pSS patients and the controls by the robust rank aggregation (RRA) method. We explored DEGs\u2019 potential function using gene function annotation and PPI network analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n GSE23117<\/jats:ext-link>\n ,\n GSE40611<\/jats:ext-link>\n ,\n GSE80805<\/jats:ext-link>\n , and\n GSE127952<\/jats:ext-link>\n were included, including 38 patients and 30 controls. The RRA integrated analysis determined 294\u00a0significant DEGs (241 upregulated and 53 downregulated), and the most significant gene aberrantly expressed in SS was CXCL9 (\n p<\/jats:italic>\n \u00a0=\u00a06.39E\u201015), followed by CXCL13 (\n p<\/jats:italic>\n \u00a0=\u00a01.53E\u201013). Immune response (GO:0006955;\n p<\/jats:italic>\n \u00a0=\u00a04.29E\u201032) was the most significantly enriched biological process in GO (gene ontology) analysis. KEGG pathway enrichment analysis showed that cytokine\u2013cytokine receptor interaction (hsa04060;\n p<\/jats:italic>\n \u00a0=\u00a06.46E\u201010) and chemokine signaling pathway (hsa04062;\n p<\/jats:italic>\n \u00a0=\u00a09.54E\u201009) were significantly enriched. We defined PTPRC, CD86, and LCP2 as the hub genes based on the PPI results.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our integrated analysis identified gene signatures and helped understand molecular changes in pSS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.13943","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T07:51:03Z","timestamp":1624089063000},"page":"1831-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Integrated analysis of transcriptomics to identify hub genes in primary\n Sj\u00f6gren's<\/scp>\n syndrome"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-8818","authenticated-orcid":false,"given":"Yanjun","family":"Lin","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases Fujian Medical University Fuzhou Fujian China"},{"name":"Fujian Provincial Engineering Research Center of Oral Biomaterial Fujian Medical University Fuzhou Fujian China"},{"name":"Stomatological Key Lab of Fujian College and University Fuzhou Fujian China"},{"name":"Department of Oral Implantology School and Hospital of Stomatology Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Yao","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases Fujian Medical University Fuzhou Fujian China"},{"name":"Research Center of Dental Esthetics and Biomechanics Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdong","family":"Yan","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases Fujian Medical University Fuzhou Fujian China"},{"name":"Department of Oral Implantology School and Hospital of Stomatology Fujian Medical University Fuzhou Fujian China"},{"name":"Laboratory of Oral Tissue Engineering Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-6112","authenticated-orcid":false,"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology School and Hospital of Stomatology Fujian Medical University Fuzhou Fujian China"},{"name":"Research Center of Dental and Craniofacial Implants Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology School and Hospital of Stomatology Fujian Medical University Fuzhou Fujian China"},{"name":"Research Center of Dental and Craniofacial Implants Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department 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