{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:26:01Z","timestamp":1789471561510,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202078"],"award-info":[{"award-number":["7202078"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570445"],"award-info":[{"award-number":["81570445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity contributes to the dysfunction of salivary gland. To explore the specific underlying mechanism for obesity\u2010induced hyposalivation, a model for high\u2010fat diet\u2010induced obese (DIO) mice were constructed to analyze long non\u2010coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The DIO group and control group were fed a diet containing 60\u00a0kcal% fat and a normal chow diet for 16\u00a0weeks respectively. Microarray analyses were performed to detect the expression profiles of lncRNA and mRNA in submandibular gland tissues from control group mice and DIO mice. Gene ontology, kyoto encyclopedia of genes and genomes, protein\u2013protein interaction, coding\u2010non\u2010coding gene co\u2010expression, transcription factors and competing endogenous RNA analyses were performed to examine the function of differentially expressed genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Microarray analyses identified that 624\u00a0lncRNAs, along with 297\u00a0mRNAs were differentially expressed. Bioinformatic analyses revealed that \u201ccomplement and coagulation cascades,\u201d \u201cglutathione metabolism,\u201d \u201ccysteine and methionine metabolism,\u201d and \u201cestrogen signaling pathway\u201d were significantly associated with candidate lncRNAs. Transcription factors analysis on candidate lncRNAs revealed several genes such as tribbles pseudokinase 3 may play regulatory roles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results revealed the expression profiles of lncRNAs and mRNAs and provided new insights into the mechanism of obesity\u2010induced hyposalivation using bioinformatic analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13952","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:10:40Z","timestamp":1625116240000},"page":"1846-1860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated analysis of lncRNA and mRNA expression profiles in the submandibular glands of DIO mice"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-4942","authenticated-orcid":false,"given":"Hui\u2010Min","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-1911","authenticated-orcid":false,"given":"Ruo\u2010Lan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences  Beijing 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