{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:43Z","timestamp":1772160823703,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Since Wnt signaling plays an important role in both tooth agenesis and altered intestine homeostasis, the aim was to compare gastrointestinal symptoms in patients with isolated oligodontia caused by a Wnt pathway gene mutation and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control study was designed to compare self\u2010reported gastrointestinal symptoms among patients with isolated oligodontia, caused by a Wnt signaling gene mutation, and fully dentate controls. The Gastrointestinal Symptom Rating Scale (GSRS) was used to assess gastrointestinal symptoms. Prevalence and severity of gastrointestinal symptoms among patients and age\u2010 and gender\u2010matched controls were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients with isolated oligodontia and a pathogenic variant in the wnt pathway genes\n                      <jats:italic>WNT10A<\/jats:italic>\n                      ,\n                      <jats:italic>LRP6<\/jats:italic>\n                      , or\n                      <jats:italic>PAX9<\/jats:italic>\n                      participated. The prevalence of gastrointestinal symptoms was higher in the oligodontia patients compared to their controls (\u03a7\n                      <jats:sup>2<\/jats:sup>\n                      (1)\u00a0=\u00a087.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008). Mean GSRS total scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.011) and domain scores for \u201cabdominal pain\u201d (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.022), \u201creflux\u201d (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003) and constipation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.030) were higher for these oligodontia patients compared to their controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gastrointestinal symptoms are more prevalent and more severe in patients with isolated oligodontia and a deficiency in a Wnt pathway\u2010related gene, when compared to controls without tooth agenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13954","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T15:06:18Z","timestamp":1625583978000},"page":"300-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastrointestinal symptoms in patients with isolated oligodontia and a Wnt gene mutation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1540-8792","authenticated-orcid":false,"given":"Jamila N.","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery, Prosthodontics and Special Dental Care University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisanne C.","family":"Ruigrok","sequence":"additional","affiliation":[{"name":"Department of Fixed and Removable, Prosthodontics and Biomaterials Center for Dentistry and Oral Hygiene University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem M.M.","family":"Fennis","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery, Prosthodontics and Special Dental Care University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco S.","family":"Cune","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery, Prosthodontics and Special Dental Care University Medical Center Utrecht  Utrecht the Netherlands"},{"name":"Department of Fixed and Removable, Prosthodontics and Biomaterials Center for Dentistry and Oral Hygiene University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Oral\u2010Maxillofacial Surgery, Prosthodontics and Special Dental Care St. Antonius Hospital Nieuwegein  Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine J.W.P.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery, Prosthodontics and Special Dental Care University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick B.","family":"van Nunen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology Zuyderland Medical Center  Heerlen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijn A.","family":"Cr\u00e9ton","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery, Prosthodontics and Special Dental Care University Medical Center Utrecht  Utrecht the Netherlands"},{"name":"Department of Dentistry Radboud Institute for Health Sciences Section of Orthodontics and Craniofacial Biology Radboud university medical center  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Kristian","family":"Ploos van Amstel","sequence":"additional","affiliation":[{"name":"Department of Genetics University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Jos\u00e9 J.H.","family":"van den Boogaard","sequence":"additional","affiliation":[{"name":"Department of Genetics University Medical Center Utrecht  Utrecht the 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