{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:49:57Z","timestamp":1791654597514,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 di Catania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of two different therapies on oral lichen planus (OLP) treatment through the analysis of OLP symptoms and signs and to analyze the risk of side effects related to the adopted protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010eight patients with OLP were selected according to van der Meij and van der Waal clinical and histopathological criteria. Through a randomized design, 19 patients received Tacrolimus 0.1% ointment (T group) and 19 an anti\u2010inflammatory mouthwash (M group) composed of calcium hydroxide 10%, hyaluronic acid 0.3%, umbelliferone, and oligomeric proanthocyanidins. The patients were examined on a regular basis for OLP symptoms, signs, and disease severity score changes over a 3\u2010month follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both treatments were effective in the reduction of OLP signs and symptoms. However, at 3\u00a0months (T3), in comparison with the M group, T group patients showed significantly lower mean values of OLP signs (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.035), symptoms (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.045), and disease severity scores (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.041). Moreover, the Spearman test showed that there was a significant correlation between OLP signs and symptoms at each follow\u2010up session in all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both treatments demonstrated a significant approach to control OLP. However, tacrolimus determined a more effective improvement in OLP signs and symptoms compared to anti\u2010inflammatory mouthwash at 3\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13960","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T14:51:36Z","timestamp":1626101496000},"page":"755-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Analysis of the response to two pharmacological protocols in patients with oral lichen planus: A randomized clinical trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-8899","authenticated-orcid":false,"given":"Alessandro","family":"Polizzi","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-4341","authenticated-orcid":false,"given":"Simona","family":"Santonocito","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-2348","authenticated-orcid":false,"given":"Antonino","family":"Lo Giudice","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-151X","authenticated-orcid":false,"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economical, Business and Environmental Sciences and Quantitative Methods University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-8946","authenticated-orcid":false,"given":"Rocco","family":"De Pasquale","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties Unit of Dermatology, University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.11.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12128"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u20106\u20107"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.03.016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1590952"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100714.2003.00173.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632016652906"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0302"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000232287.08903.1d"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12885"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/742826"},{"issue":"5","key":"e_1_2_10_14_1","first-page":"466","article-title":"Long\u2010term efficacy and safety of topical tacrolimus in the management of ulcerative\/erosive oral lichen planus","volume":"13","author":"Hodgson T. 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