{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:43:49Z","timestamp":1784825029797,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Neutrophil granulocytes have been proposed to play a major role in the mediation of periodontitis\u2010associated tissue destruction. Their recruitment and activation are regulated by the chemokine CXCL8. This study aimed to delineate the dependency of CXCL8 expression in gingival crevicular fluid (GCF) and saliva on periodontal status, bacterial infection, and smoking, in patients with periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort comprised 279\u00a0subjects with untreated periodontitis. Probing pocket depth (PPD), gingival recession, bleeding on probing (BOP), plaque index, and bone loss were evaluated. CXCL8 was determined in saliva and GCF using flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Considering the entire study sample, CXCL8\u00a0levels were correlated with the mean PPD (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.131;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029), severity of periodontitis (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.121;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043), BOP (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.204;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), and smoking (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.219;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) in GCF; and, in whole saliva, with mean PPD (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.154;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.010) severity of periodontitis (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.140;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.020), gender (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.178;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), and smoking (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.156;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.010). Subgroup analysis among non\u2010smokers revealed significantly higher amounts of CXCL8 in GCF (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012) and saliva (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.026) comparing subjects with mean PPD \u22643mm and &gt;3mm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current study revealed a strong dependency of CXCL8 expression in GCF on the severity and activity of periodontal disease. Smoking causes a significant reduction in CXCL8 expression in saliva and GCF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13994","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T12:49:49Z","timestamp":1628858989000},"page":"2267-2276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Salivary and gingival CXCL8 correlation with periodontal status, periodontal pathogens, and smoking"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-6585","authenticated-orcid":false,"given":"Iris","family":"Frasheri","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Heym","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ern","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Summer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till G.","family":"Hennessen","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"H\u00f6gg","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz\u2010Xaver","family":"Reichl","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4708-784X","authenticated-orcid":false,"given":"Matthias","family":"Folwaczny","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.1.225"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010018\u20100039\u2010z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12940"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1997.tb00483.x"},{"key":"e_1_2_10_6_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1396106"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"36","article-title":"The application of periodontal screening and recording (PSR) in a military population","volume":"4","author":"Covington L. 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