{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:58:20Z","timestamp":1772953100332,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the oral shedding and viremia of Epstein\u2013Barr virus (EBV) in HIV\u2010positive patients and their relationship with oral hairy leukoplakia (OHL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A total of 94 HIV\u2010positive patients were included in the study, in which blood and saliva samples were collected for EBV quantification. Data on gender, age, time of HIV seropositivity, combined antiretroviral therapy (cART), CD4+ T\u2010cell counts, and HIV viral load were collected. OHL diagnosis was based on histopathological examination and EBV in situ hybridization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The EBV load in the 94 HIV\u2010positive patients was higher in saliva than in blood (2.4 and 1.6, respectively), and there was a positive correlation between EBV oral shedding and viremia (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). Twenty (21.27%) patients had OHL and also a higher EBV load in saliva (mean log\n                      <jats:sub>10<\/jats:sub>\n                      \u00a0=\u00a03.11) compared to those who had no OHL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.045). Presence of OHL was only associated with age (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In HIV\u2010positive patients, the presence of OHL was associated with EBV oral shedding but not with viremia, regardless of the amount of circulating CD4+ T cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14001","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T15:02:23Z","timestamp":1628694143000},"page":"796-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Epstein\u2013Barr virus oral shedding and viremia and their association with oral hairy leukoplakia in HIV+ individuals"],"prefix":"10.1111","volume":"29","author":[{"given":"Jos\u00e9 Henrique Feij\u00f3","family":"Rosseto","sequence":"first","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-9148","authenticated-orcid":false,"given":"Jefferson Rocha","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Pathology and Oral Diagnosis School of Dentistry Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Mamana","sequence":"additional","affiliation":[{"name":"Laboratory of Virology School of Medicine Institute of Tropical Medicine of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e2nia Regina","family":"Tozetto\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Laboratory of Virology School of Medicine Institute of Tropical Medicine of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Silva","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry Federal University of Sergipe  Lagarto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9521","authenticated-orcid":false,"given":"Paulo Henrique","family":"Braz\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Laboratory of Virology School of Medicine Institute of Tropical Medicine of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-2858","authenticated-orcid":false,"given":"Karem L.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(90)90322\u2010j"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010018\u20103591\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010007\u20100039\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20380"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3239036491"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu634"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.11.012"},{"issue":"10","key":"e_1_2_10_9_1","first-page":"1121","article-title":"The association between cigarette smoking and selected HIV\u2010related medical conditions","volume":"10","author":"Conley L. 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