{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:54:13Z","timestamp":1773147253475,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objectives of this study were to estimate the prognostic value of the tumour\u2010stroma ratio (TSR) and tumour budding (TB) in oral tongue squamous cell carcinoma (OTSCC) and to establish a reliable model to predict the outcome of OTSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 103 patients surgically treated at our hospital were enrolled in this study. Chi\u2010square tests, Kaplan\u2013Meier analyses and Cox proportional hazards regression models were performed for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010six patients were categorized as stroma\u2010rich, and 47 patients were categorized as stroma\u2010poor. Only pathological grade was associated with the TSR (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017). Kaplan\u2013Meier analysis showed that stroma\u2010rich, high\u2010intensity budding and high risk groups were associated with worse prognosis. The Cox regression model showed that the TSR was an independent risk factor for OTSCC patients prognosis, and the high risk group was also related to poor prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). TB was significantly associated with poor prognosis but was not an independent risk factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that patients in the stroma\u2010rich group had a worse long\u2010term prognosis. The TSR is an independent risk factor for OTSCC patients\u2019 outcome. In addition, a risk model that combined the TSR and TB proved to be valuable for predicting OTSCC patients\u2019 outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14013","type":"journal-article","created":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T13:48:30Z","timestamp":1630244910000},"page":"628-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tumour\u2010stroma ratio is a valuable prognostic factor for oral tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Jia","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology Beijing Stomatological Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck 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