{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:26:32Z","timestamp":1785893192717,"version":"3.56.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the oral shedding of herpes viruses in patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) and investigate its relationship with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Polymerase chain reaction and enzymatic digestion were performed to identify the oral shedding of the members of the\n                      <jats:italic>Herpesviridae<\/jats:italic>\n                      family in 31 patients. The samples were collected from the oral cavity at five timestamps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The presence of each herpesvirus in the oral cavity was observed in 3.2%, 12.9%, 19.3%, 32.2%, 54.8% and 93.5% patients for human herpesvirus (HHV)\u20106A, herpes simplex virus\u20101, HHV\u20106B, cytomegalovirus (CMV), Epstein\u2013Barr virus (EBV) and HHV\u20107, respectively. Oral shedding of herpes virus was not uncommon after alloHSCT. There was a statistically significant association between the EBV and CMV oral shedding at C1 and the cumulative incidence of acute graft\u2010versus\u2010host disease (aGVHD). The results suggested that the presence of HSV\u20101 at C2 was related to a relapse. The HHV\u20107 oral shedding at C2 suggests a possible link between relapse, progression\u2010free survival and overall survival of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients who developed aGVHD showed higher CMV and EBV shedding in the oral cavity at aplasia, suggesting modifications to the pattern of immune cell response and inflammatory microenvironment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14022","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T23:41:22Z","timestamp":1631662882000},"page":"815-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral shedding of herpesviruses and clinical outcomes in hematopoietic stem cell transplant 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