{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:49:48Z","timestamp":1792399788437,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify possible associations between patients\u2019 demographics and habits and the clinical aspects and histopathological characteristics of oral leukoplakia (OL) at patients\u2019 first visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 140 consecutive patients with OL at a single institute between 1997 and 2019. All biopsies were microscopically examined for classic dysplasia (CD) (WHO definition oral epithelial dysplasia) and differentiated dysplasia (DD) known from differentiated vulvar intraepithelial neoplasia. Clinical characteristics were correlated to histopathological diagnosis and odds ratios (OR) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 96 females and 44\u00a0males, mean age 58\u00a0years, were presented. OLs were found mainly on the tongue (41%) and floor of mouth (FOM) (18%). Homogeneous OLs (58%) were associated with smoking, FOM and size &lt;2cm and non\u2010homogeneous OLs (42%) with non\u2010smokers. No dysplasia was present in 40% and any dysplasia (AD) in 60%. Tongue OLs were correlated with AD (OR:6.0) and CD (OR:5.7). FOM OLs were correlated with CD (OR:4.5). DD was correlated with non\u2010homogeneous OLs (OR:2.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CD was most frequently observed in tongue and FOM OLs, while DD was associated with non\u2010homogeneous OLs. In this series of patients, there was no consistent reliable association between the clinical and histopathological features and clinical characteristics can therefore not substitute microscopic examination of biopsies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14038","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T15:55:30Z","timestamp":1633362930000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Associations between clinical and histopathological characteristics in oral leukoplakia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-3300","authenticated-orcid":false,"given":"Ilkay","family":"Evren","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology Amsterdam UMC, Location VUmc, Cancer Center Amsterdam Academic Center for Dentistry Amsterdam (ACTA)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-7452","authenticated-orcid":false,"given":"Elisabeth R.","family":"Brouns","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology Amsterdam UMC, Location VUmc, Cancer Center Amsterdam Academic Center for Dentistry Amsterdam (ACTA)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-3779","authenticated-orcid":false,"given":"Jos B.","family":"Poell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Amsterdam UMC, Location VUmc, Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-3751","authenticated-orcid":false,"given":"Leon J.","family":"Wils","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology Amsterdam UMC, Location VUmc, Cancer Center Amsterdam Academic Center for Dentistry Amsterdam (ACTA)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-5378","authenticated-orcid":false,"given":"Ruud\u00a0H.","family":"Brakenhoff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Amsterdam UMC, Location VUmc, Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-9538","authenticated-orcid":false,"given":"Elisabeth","family":"Bloemena","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology Amsterdam UMC, Location VUmc, Cancer Center Amsterdam Academic Center for Dentistry Amsterdam (ACTA)  Amsterdam The Netherlands"},{"name":"Department of Pathology Amsterdam UMC, Location VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-1041","authenticated-orcid":false,"given":"Jan G.A.M.","family":"de Visscher","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology Amsterdam UMC, Location VUmc, Cancer Center Amsterdam Academic Center for Dentistry Amsterdam (ACTA)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010010\u20100157\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010013\u20101412\u20106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100528.1984.tb01428.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.07.025"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"773","article-title":"The frequency and malignant transformation rate of oral lichen planus and leukoplakia\u2013a retrospective study","volume":"36","author":"Brzak B. 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