{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:42:15Z","timestamp":1787784135729,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Tongue squamous cell carcinoma is one of the most common carcinomas in oral cancer with a high morbidity and mortality. Ferroptosis is a novel type of cell death involved in various diseases including cancers. Additionally, Enhancer of Zeste homolog 2 (EZH2) is significantly associated with a poor prognosis in esophageal squamous cell carcinoma patients but its role in TSCC is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this study, we tried to investigate the possible mechanism of EZH2 involved in the ferroptosis of TSCC. Expression of EZH2 and SLC7A11 was determined by RT\u2010qPCR. CCK\u20108 assays were performed to quantify the cell death rate of TSCC cells. Malondialdehyde (MDA) assays were performed to quantify the lipid accumulation. Western blot was performed to analyze the expression level of SLC7A11. We used dual\u2010luciferase reporter assays to determine the association between EZH2 and miR\u2010125b\u20105p promoter, and miR\u2010125b\u20105p and the SLC7A11 3\u2019 untranslated region (UTR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Overexpression of EZH2 and SLC7A11 inhibits erastin\u2010induced ferroptosis in TSCC cells. MiR\u2010125b\u20105p regulates ferroptosis in TSCC cells by targeting SLC7A11. EZH2 inhibits the ferroptosis of TSCC cells by inhibiting miR\u2010125b\u20105p and enhancing SLC7A11.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EZH2 inhibits erastin\u2010induced ferroptosis in TSCC cells via miR\u2010125b\u20105p\/SLC7A11 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14040","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T05:32:36Z","timestamp":1633671156000},"page":"880-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["EZH2\u2010mediated SLC7A11 upregulation via miR\u2010125b\u20105p represses ferroptosis of TSCC"],"prefix":"10.1111","volume":"29","author":[{"given":"Yue","family":"Yu","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery Ward The First Affiliated Hospital of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"MohamedAl\u2010Sharani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery College of Dentistry Ibb University  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-806X","authenticated-orcid":false,"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Ward The First Affiliated Hospital of Jinzhou Medical University  Jinzhou 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