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However, it remains largely unknown about how NFIC functions in dentin and enamel formation. In the present review, we aim to summarize the most recent discoveries in the field and gain a better understanding of the roles NFIC performs during tooth formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Nfic<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice exhibit human dentin dysplasia type I (DDI)\u2010like phenotypes signified by enlarged pulp chambers, the presence of short\u2010root anomaly, and failure of odontoblast differentiation. Although loss of NFIC has little effect on molar crown morphology, researchers have detected aberrant microstructures of enamel in the incisors. Recently, accumulating evidence has further uncovered the novel function of NFIC in the process of enamel and dentin formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During epithelial\u2010mesenchyme crosstalk, the expression of NFIC is under the control of\n                      <jats:italic>SHH\u2010PTCH\u2010SMO\u2010GLI1<\/jats:italic>\n                      pathway. NFIC is closely involved in odontoblast lineage cells proliferation and differentiation, and the maintenance of NFIC protein level in cytoplasm is negatively regulated by TGF\u2010\u03b2 signaling pathway. In addition, NFIC has mild effect on ameloblast differentiation, enamel mineralization and cementum formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NFIC plays an important role in tooth development and is required for the formation of dentin, enamel as well as cementum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14046","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T23:32:52Z","timestamp":1634081572000},"page":"2093-2099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The critical role of nuclear factor I\u2010C in tooth development"],"prefix":"10.1111","volume":"28","author":[{"given":"Chunmei","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Periodontics National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Periodontics National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-3114","authenticated-orcid":false,"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Periodontics National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Periodontics National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-8442","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Periodontics National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100185(199707)248:3<332:AID\u2010AR5>3.0.CO;2\u2010R"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gep.2013.04.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3598"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735\u2010014\u20109588\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.159"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12151"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20101119(00)00140\u20102"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.06.034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.02.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010021\u201000114\u20108"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2009.12223046"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2015.48.3.188"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"173","article-title":"Tissue interactions in embryonic mouse tooth germs. 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