{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:43Z","timestamp":1772160823667,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Both zoledronic acid, a potent bisphosphonate, and the antiangiogenic drug sunitinib are included in anticancer protocols and have also been associated with jaw osteonecrosis. Our aim was to compare the effect of these drugs on tissue repair at tooth extraction sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wistar rats were allocated into four groups: (1) sunitinib; (2) sunitinib\/zoledronic acid; (3) zoledronic acid; (4) control group. The animals underwent tooth extractions and maxillae were macro\u2010 and microscopically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On macroscopic evaluation, the zoledronic acid group showed a significantly higher frequency of oral mucosal lesion; lesions in the sunitinib\/zoledronic acid group were larger, albeit not significantly so. The sunitinib\/zoledronic acid group had significantly less epithelium than the zoledronic acid and control group, but showed no significant difference compared to the sunitinib group. The sunitinib\/zoledronic acid and zoledronic acid groups did not differ from each other, but had significantly less connective tissue and more non\u2010vital bone and microbial colonies than sunitinib and control groups, whereas these latter two groups did not significantly differ from each other. Vital bone and inflammatory infiltrate did not significantly differ between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sunitinib alone is not associated with non\u2010vital bone, whereas the sunitinib\/zoledronic acid combination and zoledronic acid alone are.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14065","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T13:03:37Z","timestamp":1635771817000},"page":"1070-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of tyrosine kinase inhibitor\n                    <i>sunitinib<\/i>\n                    on tissue repair at tooth extraction sites"],"prefix":"10.1111","volume":"29","author":[{"given":"Bruna","family":"Ratzkowski","sequence":"first","affiliation":[{"name":"School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-7347","authenticated-orcid":false,"given":"Valesca S.","family":"Koth","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan A.","family":"Azambuja","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Lucas Pontifical Catholic University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda G.","family":"Salum","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A. 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