{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:20:23Z","timestamp":1790360423318,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Main aim of the study was to explore the association between genetic polymorphisms in\n                      <jats:italic>ACTN3<\/jats:italic>\n                      and bruxism. Secondary objectives included masseter muscle phenotypes assessment between bruxers and non\u2010bruxers and according to genetic polymorphisms in\n                      <jats:italic>ACTN3<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients undergoing orthognathic surgery for correction of their malocclusion were enrolled. Self\u2010reported bruxism and temporomandibular disorders status were preoperatively recorded. Saliva samples were used for\n                      <jats:italic>ACTN3<\/jats:italic>\n                      genotyping. Masseter muscle samples were collected bilaterally at the time of orthognathic surgery to explore the muscle fiber characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant differences in genotypes for rs1815739 (R577X nonsense) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), rs1671064 (Q523R missense) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), and rs678397 (intronic variant) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) between bruxers and non\u2010bruxers. Patients with self\u2010reported bruxism presented a larger mean fiber area for types IIA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035). The mean fiber areas in individuals with the wild\u2010type CC genotype for rs1815739 (R577X) were significantly larger for type IIA fibers (1394.33\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      [572.77\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ]) than in those with the TC and TT genotypes (832.61\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      [602.43\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ] and 526.58\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      [432.21\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ] [\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014]). Similar results for Q523R missense and intronic variants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ACTN3 genotypes influence self\u2010reported bruxism in patients with dentofacial deformity through specific masseter muscle fiber characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14075","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T03:43:28Z","timestamp":1636775008000},"page":"232-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>ACTN3<\/i>\n                    genotype influences masseter muscle characteristics and self\u2010reported bruxism"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-2121","authenticated-orcid":false,"given":"Romain","family":"Nicot","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Lille CHU Lille INSERM U 1008: Controlled Drug Delivery Systems and Biomaterials  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gw\u00e9na\u00ebl","family":"Raoul","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Lille CHU Lille INSERM U 1008: Controlled Drug Delivery Systems and Biomaterials  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-6881","authenticated-orcid":false,"given":"Alexandre R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral Biology University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Lille CHU Lille INSERM U 1008: Controlled Drug Delivery Systems and Biomaterials  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Sciote","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12914"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.060293"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005083"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12821"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3144-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12749"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4625-44.3.8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12496"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90252-8"},{"key":"e_1_2_11_11_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: Review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin S. 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