{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:27Z","timestamp":1787015967705,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["459672\/2014\u20102"],"award-info":[{"award-number":["459672\/2014\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate psychological (anxiety, depression, and stress) and salivary (flow and concentration of \u03b1\u2010amylase) profile associated with oral lichen planus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A case\u2013control preliminary study with oral lichen planus patients and age\u2013gender matched controls was conducted. The participants underwent psychological tests (Beck depression and anxiety inventories and perceived stress scale) and saliva collection to determine the unstimulated salivary flow and \u03b1\u2010amylase levels at three moments along the day. The data were analyzed statistically using Mann\u2013Whitney, McNemar chi\u2010square and Friedman tests, and the Spearman correlation coefficient. The significance level adopted was 5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 46 case\u2013control pairs were recruited. There was a significant correlation between anxiety, depression, stress, and oral lichen planus, as well as the stress and decline of salivary \u03b1\u2010amylase levels. Higher concentrations of this biomarker were found in the case group thirty minutes post\u2010awakening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The applied psychological tests indicated that factors such as anxiety, depression, and stress were associated with oral lichen planus. Salivary analyses demonstrated a higher concentration of \u03b1\u2010amylase thirty minutes post\u2010awakening on individuals with the disease and its decline correlated with stress, suggesting the role of \u03b1\u2010amylase as a promising biomarker for future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14081","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T13:13:22Z","timestamp":1637327602000},"page":"1242-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Psychological profile and \u03b1\u2010amylase levels in oral lichen planus patients: A case\u2013control preliminary study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-4206","authenticated-orcid":false,"given":"Juliana Ara\u00fajo da Silva","family":"Simoura","sequence":"first","affiliation":[{"name":"Department of Health Sciences Universidade 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