{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:31:00Z","timestamp":1782228660904,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/18444\u20106"],"award-info":[{"award-number":["2018\/18444\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the serum and salivary levels of IL\u20101\u03b2, IL\u20106, IL\u201017A, TNF\u2010\u03b1, IL\u20104, and IL\u201010 in patients with oral lichen planus (OLP) treated with Photobiomodulation (PBM) and clobetasol propionate 0.05%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four OLP patients were randomized into two groups: Control (clobetasol propionate 0.05%) and PBM (660\u00a0nm, 100\u00a0mW, 177\u00a0J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 5\u00a0s, 0.5\u00a0J per point). Serum and saliva were collected at baseline and at the end of treatment (after 30\u00a0days) and evaluated using ELISA. The cytokine results were correlated with pain, clinical subtypes, and clinical scores of OLP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL\u20101\u03b2, IL\u20106, IL\u201017A, TNF\u2010\u03b1, and IL\u20104 levels were higher in saliva in relation to serum. IL\u20101\u03b2 was the most concentrated cytokine in saliva, and a positive correlation with the severity of OLP was noticed. After treatment with corticosteroid, IL\u20101\u03b2 in saliva decreased significantly. No modulation of all cytokines was observed after PBM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u20101\u03b2 appears to be an important cytokine involved in OLP pathogenesis. In addition, the mechanisms of action of PBM do not seem to be linked to the modulation of pro or anti\u2010inflammatory cytokines at the end of treatment. It is possible that this events occurred early during treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14084","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T03:02:53Z","timestamp":1637809373000},"page":"1250-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Serum and salivary cytokines in patients with oral lichen planus treated with Photobiomodulation"],"prefix":"10.1111","volume":"29","author":[{"given":"Clery Saad","family":"Abboud","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00edza Helena da Silva","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University 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