{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:10:22Z","timestamp":1791227422417,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the risk factors associated with xerostomia and hyposalivation in a group of hypertensive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted. Hypertensive patients belonged to two healthcare centers were included. Xerostomia was assessed by asking a question and using the Xerostomia Inventory. Unstimulated salivary flow was collected. Different epidemiological variables were analyzed such as age, sex, habits, diseases, drugs, and blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>221 individuals were included. Xerostomia was reported in 51.13% of patients. Patients with xerostomia suffered more from osteoarthritis and diaphragmatic hernia. These patients took more anticoagulants (acenocoumarol), antiarrhythmics (amiodarone), analgesics (paracetamol) and epilepsy drugs (pregabalin) and less platelet aggregation inhibitors and angiotensin II receptor blockers (losartan). Unstimulated flow was reduced in 37.56% of patients. Patients suffering hyposalivation presented more diseases such as anxiety, infectious or parasitic diseases, hepatitis C, diaphragmatic hernia, and osteoarthritis. These patients took more repaglinide, thiazides, anti\u2010inflammatories, anti\u2010rheumatics, glucosamine, diazepam, and selective beta\u20102\u2010adrenoreceptor agonists and less combinations of candesartan and diuretics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Xerostomia and hyposalivation are frequent in hypertensive patients. It is advisable to take into consideration the comorbidities and the drugs they receive, since they can increase the risk of these salivary disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14090","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T11:23:50Z","timestamp":1638098630000},"page":"1299-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk factors associated with xerostomia and reduced salivary flow in hypertensive patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Luc\u00eda","family":"Ram\u00edrez","sequence":"first","affiliation":[{"name":"Department of Dental Clinical Specialties, ORALMED Research Group, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, ORALMED Research Group, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, School of Biomedical Science European University of Madrid  Villaviciosa de Od\u00f3n, Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Mart\u00ednez\u2013Acitores","sequence":"additional","affiliation":[{"name":"Adelfas Health\u2010Care Centre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Garrido","sequence":"additional","affiliation":[{"name":"Canal de Panama Health\u2010Care Centre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, ORALMED Research Group, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0920","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"L\u00f3pez\u2010Pintor","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, ORALMED Research Group, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51867"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.10.027"},{"key":"e_1_2_8_4_1","volume-title":"Therapeutic uses of diuretic agents","author":"Arumugham V. 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