{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:27Z","timestamp":1787015967577,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T00:00:00Z","timestamp":1639267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The current study aims to evaluate and compare the lipocalin, adiponectin and periodontal viruses in the generalized periodontitis patients with and without diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Seventy subjects were grouped into 35 systemically healthy (GP) and 35 patients with diabetes mellitus (GP+DM). The periodontal parameters, demographic and diabetic variables were evaluated in both the groups. The subgingival tissue samples were procured from the diseased sites and were analysed for the detection of EBV, CMV, HSV and protein markers by real\u2010time polymerase chain reaction (RT\u2010PCR) and lipocalin and adiponectin were identified by enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The demographic variables such as age and BMI did not differ between the groups. PI and CAL were found to be significantly higher in GP+DM (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). EBV (82.9%), CMV (71.4%) and protein marker: lipocalin were also found to be statistically highly significant in GP+DM and adiponectin was found to be higher in GP group and reduced in GP+DM group (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The increased prevalence of EBV and CMV and lipocalin with reduced levels of adiponectin in patients with diabetes and periodontitis which may show aggravation of the diabetic status of the periodontitis patients thereby reinforcing a strong Periodontitis\u2010DM continuum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14091","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:22:39Z","timestamp":1638310959000},"page":"1163-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Epstein\u2013Barr virus, cytomegalovirus and lipocalin with periodontitis in type 2 diabetic subjects"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-3727","authenticated-orcid":false,"given":"Jaideep","family":"Mahendra","sequence":"first","affiliation":[{"name":"Department of Periodontics Meenakshi Ammal Dental College and Hospital  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Little","family":"Mahendra","sequence":"additional","affiliation":[{"name":"Department of Periodontics Maktoum bin Hamdan Dental University  Dubai United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhana","family":"divya","sequence":"additional","affiliation":[{"name":"Department of Periodontics Sri Ramachandra Dental College and Hospital  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paavai","family":"Ilango","sequence":"additional","affiliation":[{"name":"Department of Periodontics Priyadarshini Dental College and Hospital  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Central research laboratory Meenakshi Ammal Dental College and Hospital  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abirami","family":"Thanigaimalai","sequence":"additional","affiliation":[{"name":"Department of Periodontics Priyadarshini Dental College and Hospital  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,12]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"52","article-title":"Periodontal health and biochemical study on saliva and gingival crevicular fluid among diabetics and non\u2010 diabetics","volume":"20","author":"Abaas R.","year":"2006","journal-title":"Journal of Baghdad College of Dentistry"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061321"},{"key":"e_1_2_11_4_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"issue":"5","key":"e_1_2_11_5_1","first-page":"1","article-title":"A comparative study on serum leptin and adiponectin levels in periodontitis patients with and without diabetes Mellitus Type 2","volume":"3","author":"AL\u2010Azawy V. 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