{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:14:47Z","timestamp":1784664887688,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972536"],"award-info":[{"award-number":["81972536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Tertiary lymphoid structures (TLSs) provide sites for antigen presentation and activation of lymphocytes, promoting their infiltration; thus, enhancing specific immune responses. The aim of this comparative cross\u2010sectional study was to reveal the characteristics and influence of TLSs in oral lichen planus (OLP) and oral epithelial dysplasia (OED) with lichenoid features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical information and samples of 51 OLP and 19 OED with lichenoid features were collected. Immunohistochemistry was performed, and the structures where CD20+ B cells and CD3+ T cells aggregated with peripheral lymph node addressin positive (PNAd+) vessels were defined as TLSs. The results and clinical information were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      TLS were found in 44 (86.3%) patients with OLP and 19 (100%) patients with OED. The TLS score was higher in OED group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023), accompanied by an increased number of PNAd+ vessels. The TLS was significantly correlated with PNAd+ vessels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.027), CD20+ B (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and CD208+ dendritic cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). Foxp3+ Treg cells but not CD8+ T cells infiltrated more severely in OED (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) and increased when TLS score was high (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed the widespread development of TLSs in the OLP and OED. The presence of TLSs showed a close relationship with dysplasia and may increase malignant potency by over\u2010inducing Treg cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14097","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T03:46:05Z","timestamp":1639280765000},"page":"154-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tertiary lymphoid structures in oral lichen planus and oral epithelial dysplasia with lichenoid features: A comparative study"],"prefix":"10.1111","volume":"29","author":[{"given":"Meng\u2010Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Jiangsu China"},{"name":"Department of Basic Science of Stomatology the affiliated Hospital of Stomatology Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Wen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Jiangsu China"},{"name":"Department of Basic Science of Stomatology the affiliated Hospital of Stomatology Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Jiangsu China"},{"name":"Department of Basic Science of Stomatology the affiliated Hospital of Stomatology Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Jiangsu China"},{"name":"Department of Periodontology the affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run\u2010Dong","family":"Zhai","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Jiangsu China"},{"name":"Department of Basic Science of Stomatology the affiliated Hospital of Stomatology Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-922X","authenticated-orcid":false,"given":"Lai\u2010Kui","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Jiangsu China"},{"name":"Department of Basic Science of Stomatology the affiliated Hospital of Stomatology Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1914-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01516.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.01.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2014.40926"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3290"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0402-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000873"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.626776"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2360"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104688"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12859"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12996"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3836"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119132"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237465"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.032"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90315-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.584680"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.1919"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13389"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010020\u201000092\u20103"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720954134"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1387952"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0431"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2929"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02479-x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-20-0432"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23355-x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0144-6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0144-6"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2020.101406"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12904"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10090624"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5715719"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092644"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1185-0"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0019-5"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-14-38"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155420923272"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102715"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201019\u20100958"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1915574"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.14097","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T11:41:07Z","timestamp":1692531667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,20]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/odi.14097"],"URL":"https:\/\/doi.org\/10.1111\/odi.14097","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.14097\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14097\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,20]]},"assertion":[{"value":"2021-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}