{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:52:47Z","timestamp":1774644767709,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Lymphomas represent around 10% of head and neck neoplasms, among which the diffuse large B\u2010cell lymphoma (DLBCL) is the most common histologic subtype. In the present study, we characterized demographic parameters, anatomical sites, and survival rates of patients in a Brazilian cancer center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Single\u2010center retrospective epidemiological study of 243 head and neck DLBCL patients. Demographic characteristics, tumor localization, HIV status, lactate dehydrogenase (LDH) activity, and treatment modality were obtained from electronic medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most common primary head and neck tumor location in patients with DLBCL was Waldeyer's ring. Interestingly, age above 80\u00a0years, male gender, high LDH levels, and HIV positivity were significantly associated with shorter overall survival (OS) rates and increased risk of death. We further demonstrated that treatment had a protective effect, improving OS, and reducing risk of death. Notably, we found no benefit of combination of chemotherapy and radiotherapy versus isolated treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study showed that primary head and neck DLBCL is more incident in middle age and elderly patients with a small male patients\u2019 majority in a Brazilian population. Moreover, we observed a 3\u2010year OS rate of almost 60% and multivariate analysis showed that treatment was the only protective factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14104","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:53:42Z","timestamp":1639482822000},"page":"968-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary diffuse large B\u2010cell lymphoma of the head and neck in a Brazilian single\u2010center study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-8026","authenticated-orcid":false,"given":"Paula Sabbo","family":"Bernardo","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Hemato\u2010Oncologia Celular e Molecular Programa de Hemato\u2010Oncologia Molecular Instituto Nacional de C\u00e2ncer (INCA)  Rio de Janeiro 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