{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:01:55Z","timestamp":1773892915359,"version":"3.50.1"},"reference-count":104,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE025060"],"award-info":[{"award-number":["DE025060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE027103"],"award-info":[{"award-number":["DE027103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE028342"],"award-info":[{"award-number":["DE028342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Orofacial clefts (OFCs) are common craniofacial birth defects with heterogeneous phenotype and etiology. Geneticists have applied nearly every available method and technology for further understanding of the genetic architectures of OFCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review describes the evidence for a genetic etiology in OFCs, statistical genetic approaches employed to identify genetic causes, and how the results have shaped our current understanding of the genetic architectures of syndromic and nonsyndromic OFCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There has been rapid progress toward elucidating the genetic architectures of OFCs due to the availability of large collections of DNA samples from cases, controls, and families with OFCs and the consistent adoption of new methodologies and novel statistical approaches as they are developed. Genetic studies have identified rare and common variants influencing risk of OFCs in both Mendelian and complex forms of OFCs, blurring the distinction traditional categories used in genetic studies and clinical medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14109","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T01:18:54Z","timestamp":1639876734000},"page":"1327-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Genetic models and approaches to study orofacial clefts"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-1712","authenticated-orcid":false,"given":"Elizabeth J.","family":"Leslie","sequence":"first","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa050"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201002721\u20100"},{"issue":"3","key":"e_1_2_13_4_1","first-page":"348","article-title":"Association of genetic variation of the transforming growth factor\u2010alpha gene with cleft lip and palate","volume":"45","author":"Ardinger H. H.","year":"1989","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.07.011"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet\u20102017\u2010105110"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.191064"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9503.1"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.05.018"},{"issue":"3","key":"e_1_2_13_11_1","first-page":"314","article-title":"Construction of a genetic linkage map in man using restriction fragment length polymorphisms","volume":"32","author":"Botstein D.","year":"1980","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.114.165225"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy402"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22214"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22090"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201026880\u2010w"},{"issue":"1","key":"e_1_2_13_17_1","first-page":"182","article-title":"Familial recurrence\u2010pattern analysis of nonsyndromic isolated cleft palate\u2013a Danish Registry study","volume":"58","author":"Christensen K.","year":"1996","journal-title":"American Journal of Human Genetics"},{"issue":"2","key":"e_1_2_13_18_1","first-page":"177","article-title":"A genetic study of cleft lip and palate in Hawaii. II. Complex segregation analysis and genetic risks","volume":"26","author":"Chung C. S.","year":"1974","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/1294"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.04.009"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23793"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2021.100025"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22420"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa047"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.1987.tb03340.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13024"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22010"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.637306"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.258"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3182125f9c"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.069385"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520943867"},{"issue":"3","key":"e_1_2_13_35_1","first-page":"674","article-title":"Complex segregation analysis of nonsyndromic cleft lip and palate","volume":"49","author":"Hecht J. T.","year":"1991","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22343"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007501"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi\u20102018\u20100091"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008357"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.626403"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517750109"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.02.019"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010019\u20100370\u20100"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010017\u20100010\u20105"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200713"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng985"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1839"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065\u20102660(07)00410\u20105"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010016\u20101754\u20107"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.02.014"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31381"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12018"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.01.004"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv047"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23596"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51325"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14759"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102014\u201015\u20104\u2010r54"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005914"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx012"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1606"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010090711\u2010163729"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1086\/341944"},{"issue":"3","key":"e_1_2_13_66_1","first-page":"648","article-title":"Cleft lip with or without cleft palate in Shanghai, China: Evidence for an autosomal major locus","volume":"51","author":"Marazita M. L.","year":"1992","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000224636"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1086\/422475"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190104"},{"issue":"2","key":"e_1_2_13_70_1","first-page":"65","article-title":"Cleft lip and palate etiology and its meaning in early 20th century England: Galton\/Pearson vs. Bateson; polygenically poor protoplasm vs","volume":"17","author":"Melnick M.","year":"1997","journal-title":"Mendelism. J Craniofac Genet Dev Biol"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.013"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/326091a0"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517716914"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010020\u201002169\u20109"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20106343.2007.00398.x"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60695\u20104"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010019\u201002099\u20101"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.621482"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.20.21263645"},{"issue":"3","key":"e_1_2_13_80_1","first-page":"486","article-title":"Linkage of an autosomal dominant clefting syndrome (Van der Woude) to loci on chromosome Iq","volume":"46","author":"Murray J. C.","year":"1990","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21633"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.646"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.499"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.11.009"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390051048"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.242"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009584"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010018\u20100263\u20107"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.191213"},{"issue":"1","key":"e_1_2_13_90_1","first-page":"310","article-title":"Microsatellite\u2010based fine mapping of the Van der Woude syndrome locus to an interval of 4.1 cM between D1S245 and D1S414","volume":"56","author":"Sander A.","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102836(75)90213\u20102"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010018\u20100016\u2010z"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1086\/344779"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u20108628(19990521)84:2<145:aid\u2010ajmg11>3.0.co;2\u2010l"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0496"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23126"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010017\u20100362\u20102"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39458.563611.AE"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24219"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1086\/341450"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.26"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010020\u20100675\u20104"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13699"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11111280"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14364"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.14109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:23:19Z","timestamp":1692789799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/odi.14109"],"URL":"https:\/\/doi.org\/10.1111\/odi.14109","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.14109\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14109\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14109\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14109\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14109\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"2021-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}