{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:18:30Z","timestamp":1789784310513,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771084"],"award-info":[{"award-number":["81771084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse the characteristics of the oral microbiomes and expected to find biomarkers about Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>AD patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) and cognitive intact people (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) were examined for cognition, depression, oral health and collected saliva and gingival crevicular fluid (GCF) in the morning. Full\u2010length 16S rRNA gene was amplified and sequencing was performed using the PacBio platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The predominant bacterium of salivary microbiome and periodontal microbiome from AD patients was <jats:italic>Streptococcus oralis<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic>, respectively. With respect to \u03b2 diversity analysis, there was a significance difference in periodontal microbiome between AD patients and cognitively intact subjects. The relative abundance of <jats:italic>Veillonella parvula<\/jats:italic> significantly increased in oral microbiomes from AD patients. Interestingly, the dominant species were different between early\u2010onset AD and late\u2010onset AD patients. Moreover, the predominant species were changed as the clinical severity of AD. Furthermore, the correlation analysis revealed that <jats:italic>V<\/jats:italic>. <jats:italic>parvula<\/jats:italic> was associated with AD in both saliva and GCF and that <jats:italic>P<\/jats:italic>. <jats:italic>gingivalis<\/jats:italic> was associated with AD only in GCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, the microbiome community of oral microbes was altered in AD patients and periodontal microbiome was sensitive to cognition changes. Moreover, <jats:italic>V<\/jats:italic>. <jats:italic>parvula<\/jats:italic> and <jats:italic>P<\/jats:italic>. <jats:italic>gingivalis<\/jats:italic> were associated with AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14110","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T08:35:41Z","timestamp":1640075741000},"page":"1341-1355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Profiling the oral microbiomes in patients with Alzheimer's disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-6149","authenticated-orcid":false,"given":"Haiying","family":"Guo","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University  Wuhan Hubei 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