{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:52:31Z","timestamp":1792176751180,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To better characterize the histopathology of oral lichen planus and oral lichenoid lesions and to highlight the differences between them in order to support the clinician in the diagnostic and therapeutic management of such conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010five patients, clinically diagnosed with oral lichen planus (\n                      <jats:italic>n<\/jats:italic>\n                      = 25) or oral lichenoid lesions (\n                      <jats:italic>n<\/jats:italic>\n                      = 30), were consecutively enrolled in the present study. Subsequently, one blind pathologist reviewed all the biopsy specimens of enrolled subjects following a specific protocol to provide a detailed histopathological description. Demographic, anamnestic, and clinical data were also recorded from all the participants. Patients\u2019 data were analysed and compared using the chi\u2010squared test, to provide distinguishing features between the studied conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found a higher and statistically significant number of eosinophils in the oral lichenoid lesions compared with the oral lichen planus group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), an equally promising result was seen regarding plasma cells, which were more represented (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05) in the oral lichenoid lesions than in the oral lichen planus cases. No statistically significant differences were detected in demographic, anamnestic and clinical data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A mixed lichenoid inflammatory infiltrate, consisting of eosinophils and plasma cells, could be used as reliable histological features for the diagnosis of oral lichenoid lesions, as long as compared with findings obtained from the patients\u2019 history and clinical examination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14112","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T02:57:47Z","timestamp":1640314667000},"page":"1259-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Histopathology of\u00a0oral\u00a0lichen planus and\u00a0oral\u00a0lichenoid lesions: An exploratory cross\u2010sectional study"],"prefix":"10.1111","volume":"29","author":[{"given":"Michele","family":"Lodolo","sequence":"first","affiliation":[{"name":"Division of Oral Medicine Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-2239","authenticated-orcid":false,"given":"Margherita","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"},{"name":"Unit of Oral and Maxillofacial Surgery Ca Foncello Hospital  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-9726","authenticated-orcid":false,"given":"Rossana","family":"Bussani","sequence":"additional","affiliation":[{"name":"Institute of Pathological Anatomy and Histology Ospedali Riuniti and University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Torelli","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Geoscience University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-9439","authenticated-orcid":false,"given":"Katia","family":"Rupel","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3427-0514","authenticated-orcid":false,"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-4421","authenticated-orcid":false,"given":"Augusto","family":"Poropat","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Biasotto","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"issue":"25","key":"e_1_2_8_2_1","first-page":"e1","article-title":"Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations","volume":"103","author":"Al\u2010Hashimi I.","year":"2007","journal-title":"Oral Surgery, Oral Medicine, Oral 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