{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:51Z","timestamp":1787015871895,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:00:00Z","timestamp":1642291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The systemic inflammatory response caused by chronic periodontitis is a risk factor for multiple diseases. Ubiquitin\u2010specific protease 5 (USP5) is a kind of deubiquitinase which mainly responsible for dissociating unanchored polyubiquitin. However, the functions of USP5 in chronic periodontitis have not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Chronic periodontitis patients were recruited, and their periodontal samples were collected. The levels of USP5, tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and interleukin\u20101\u03b2 (IL\u20101\u03b2) in gingival crevicular fluid were evaluated by ELISA. The expression of USP5, TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 in human periodontal ligament stem cells (PDLSCs) was estimated by qRT\u2010PCR assay. The activation of STAT3 signaling was examined by Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>USP5 was upregulated in the gingival crevicular fluid and gingival tissues of chronic periodontitis patients. USP5 expression was positively correlated with the expression of proinflammatory factors. USP5 knockdown and deubiquitinase inhibitor inhibited LPS\u2010induced inflammatory responses in PDLSCs. Suppressing USP5 inhibited STAT3 signaling in PDLSCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Suppression deubiquitinase USP5 inhibits the inflammatory response of chronic periodontitis by suppressing STAT3 signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14114","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T06:34:43Z","timestamp":1640414083000},"page":"1234-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of ubiquitin\u2010specific protease 5 in the inflammatory response of chronic periodontitis"],"prefix":"10.1111","volume":"29","author":[{"given":"Qiuying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangling","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Stomatology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-909X","authenticated-orcid":false,"given":"Xun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdr.IJDR_335_17"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12237"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2741\/1817"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2018.1396876"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17144923"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201003804\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.14735\/amko20193S"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102020.vol34.0026"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.4252"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2008.01260.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1029857"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12121"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0370937"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2018.08.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009197.pub3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00216"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8295149"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010061516\u2010044916"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20109012\u20102_41"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3739"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2140"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106763"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.72"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1002\u20100098.2016.07.013"},{"issue":"2","key":"e_1_2_10_28_1","first-page":"77","article-title":"Matrix metalloproteinases in periodontitis","volume":"92","author":"Shinkarenko T. 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