{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:20:53Z","timestamp":1780363253175,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The exposure to amalgam restorations has been reported to bring about altered immunity followed by inflammation and infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed at identifying whether patients who received restorative or endodontic treatments, or tooth extraction, would have altered odds of developing oral lichen planus (OLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this population\u2010based nested case\u2013control study, 421 cases of OLP and 1,684 controls were included after propensity score matching. Logistic regression was used to estimate the adjusted odds ratio (aOR) of OLP in individuals who had received amalgam and composite resin restorations, root canal therapy, and tooth extraction over a follow\u2010up duration of five years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significantly different odds of OLP for those who underwent either amalgam (aOR = 0.948, 95% CI = 0.853\u20131.053, <jats:italic>p =<\/jats:italic> 0.3170) or resin restorations (aOR = 1.007, 95% CI = 0.978\u20131.037, <jats:italic>p =<\/jats:italic> 0.6557) in both anterior and posterior teeth in an observational period of five \u00a0years after restorations. Root canal therapy was associated with significantly lower odds of OLP, with each additional root canal therapy attenuating the risk of OLP at an aOR of 0.771 (95% CI = 0.680\u20130.874, <jats:italic>p =<\/jats:italic> 0.0001) for both anterior (aOR = 0.786, 95% CI = 0.626\u20130.986, <jats:italic>p =<\/jats:italic> 0.0372) and posterior teeth (aOR = 0.762, 95% CI = 0.650\u20130.893, <jats:italic>p =<\/jats:italic> 0.0008). Likewise, each tooth extraction reduced the risk of OLP, with an aOR of 0.846 (95% CI = 0.772\u20130.927, <jats:italic>p =<\/jats:italic> 0.0003), especially for anterior teeth (aOR = 0.733, 95% CI = 0.595\u20130.904, <jats:italic>p =<\/jats:italic> 0.0037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We reported no significant association between dental restorations and consequent OLP, and significantly lower odds of OLP following both root canal therapy and tooth extraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14115","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T11:34:56Z","timestamp":1640432096000},"page":"1269-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Onset of oral lichen planus following dental treatments: A nested case\u2013control study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-4144","authenticated-orcid":false,"given":"Kevin Sheng\u2010Kai","family":"Ma","sequence":"first","affiliation":[{"name":"Center for Global Health, Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"},{"name":"Department of Dentistry Chung Shan Medical University and Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-3196","authenticated-orcid":false,"given":"Eshwar","family":"Thota","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-799X","authenticated-orcid":false,"given":"Yu\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dentistry Chung Shan Medical University and Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"College of Oral Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0679","authenticated-orcid":false,"given":"James Cheng\u2010Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Chung Shan Medical 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