{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:55Z","timestamp":1772160835210,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["119Z195"],"award-info":[{"award-number":["119Z195"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>We compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4\u2010nitroquinoline\u20101\u2010oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that VDD and HC co\u2010exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO\u2010induced\n                      <jats:italic>in vivo<\/jats:italic>\n                      cancer models, which are suppressed by glycolysis inhibition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14117","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T03:35:40Z","timestamp":1640489740000},"page":"978-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low vitamin D and high cholesterol facilitate oral carcinogenesis in 4NQO\u2010induced rat models via regulating glycolysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Rasim","family":"Gumus","sequence":"first","affiliation":[{"name":"Molecular Biology and Genetics Department Erzurum Technical University  Erzurum Turkey"},{"name":"Cancer Therapeutics Laboratory High Technology Application and Research Center Erzurum Technical University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozel","family":"Capik","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Department Erzurum Technical University  Erzurum Turkey"},{"name":"Cancer Therapeutics Laboratory High Technology Application and Research Center Erzurum Technical University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Tatar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Diseases Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konca","family":"Altinkaynak","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Ozdemir Tozlu","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Department Erzurum Technical University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-2088","authenticated-orcid":false,"given":"Omer Faruk","family":"Karatas","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Department Erzurum Technical 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