{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:28:01Z","timestamp":1788107281911,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Whether oral lichen planus (OLP) was potentially malignant remains controversial. Here, we examined associations of\n                      <jats:italic>ZNF582<\/jats:italic>\n                      methylation (\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      ) with OLP lesions, dysplastic features and squamous cell carcinoma (OSCC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This is a case\u2013control study.\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      was evaluated in both lesion and adjacent normal sites of 42 dysplasia, 90 OSCC and 43 OLP patients, whereas\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      was evaluated only in one mucosal site of 45 normal controls. High\u2010risk habits affecting\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      such as betel nut chewing and cigarette smoking were also compared in those groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OLP lesions showed significantly lower\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      than those of dysplasia and OSCC. At adjacent normal mucosa,\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      increased from patients of OLP, dysplasia, to OSCC. In addition,\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      at adjacent normal sites in OLP patients was comparable to normal mucosa in control group. Dysplasia\/OSCC patients with high\u2010risk habits exhibited significantly higher\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      than those without high\u2010risk habits. However,\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      in OLP patients was not affected by those high\u2010risk habits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      OLP is unlikely to be potentially malignant based on\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      levels.\n                      <jats:italic>\n                        ZNF582\n                        <jats:sup>m<\/jats:sup>\n                      <\/jats:italic>\n                      may also be a potential biomarker for distinguishing OLP from true dysplastic features and OSCC, and for monitoring the malignant transformation of OLP, potentially malignant disorders with dysplastic features and OSCC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14120","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T09:55:11Z","timestamp":1640858111000},"page":"1282-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is OLP potentially malignant? 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