{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:43:06Z","timestamp":1792683786198,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The association of OLP with other autoimmune processes points to the possibility that OLP\u2010affected patients are actually developing an autoimmune status that predisposes them to autoaggression against different targets. This systematic review and meta\u2010analysis aim to evaluate the current evidence on the prevalence of autoimmune disorders in patients with OLP and their magnitude of association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, Web of Science, Scopus databases for the studies published before May 2021, with no limitation in regards to their publication date or language. We evaluated the quality of studies, carried out meta\u2010analyses and performed heterogeneity, subgroups, meta\u2010regression, and small\u2010study effects analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Inclusion criteria were met by 153\u00a0studies (23,327 patients). Our results indicate the existence of high prevalence and a frequent association between OLP and some autoimmune disorders, especially in regards to thyroid disease (PP\u00a0=\u00a07.96%, 95% CI\u00a0=\u00a06.32\u20139.75; OR\u00a0=\u00a01.99, 95% CI\u00a0=\u00a01.60\u20132.49,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) and diabetes mellitus (PP\u00a0=\u00a09.41%,95% CI\u00a0=\u00a08.16\u201310.74; OR\u00a0=\u00a01.64, 95% CI\u00a0=\u00a01.34\u20132.00,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrates the existence of a comorbidity between autoimmune thyroid diseases as well as between diabetes mellitus and OLP respectively. Quality of evidence should be upgraded on other autoimmune diseases (fibromyalgia, gastrointestinal disorders, rheumatic diseases, Sjogren's syndrome, lupus erythematosus, and dermatological diseases) for which the current data do not allow us to know whether they are really associated with OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14127","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T13:04:50Z","timestamp":1641733490000},"page":"1382-1394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Autoimmune disorders in oral lichen planus: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Teresa","family":"De Porras\u2010Carrique","sequence":"first","affiliation":[{"name":"School of Dentistry Biohealth Research Institute (Ibs.Granada) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-7772","authenticated-orcid":false,"given":"Pablo","family":"Ramos\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Dentistry Biohealth Research Institute (Ibs.Granada) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-5949","authenticated-orcid":false,"given":"Manuel","family":"Aguilar\u2010Diosdado","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Cadiz Biomedical Research and Innovation Institute (INiBICA) Puerta del Mar University Hospital  C\u00e1diz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-0746","authenticated-orcid":false,"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral and Craniofacial Sciences King's College London  London UK"},{"name":"WHO Collaborating Centre for Oral Cancer  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-6639","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Gonz\u00e1lez\u2010Moles","sequence":"additional","affiliation":[{"name":"School of Dentistry Biohealth Research Institute (Ibs.Granada) University of Granada  Granada Spain"},{"name":"WHO Collaborating Centre for Oral Cancer  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.1998.10480550"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-01"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech\u20102013\u2010203104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2019.02.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12073"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121\u2010013\u20100377\u20107"},{"issue":"4","key":"e_1_2_9_9_1","first-page":"238","article-title":"Alteraciones bioqu\u00edmicas y su correlaci\u00f3n cl\u00ednica con el liquen plano oral","volume":"5","author":"Carri\u00f3n A. 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