{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T22:21:57Z","timestamp":1783376517818,"version":"3.54.6"},"reference-count":115,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE028300"],"award-info":[{"award-number":["DE028300"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The etiology of non\u2010syndromic oral clefts (NSOFC) is complex with genetics, genomics, epigenetics, and stochastics factors playing a role. Several approaches have been applied to understand the etiology of non\u2010syndromic oral clefts. These include linkage, candidate gene association studies, genome\u2010wide association studies, whole\u2010genome sequencing, copy number variations, and epigenetics. In this review, we shared these approaches, genes, and loci reported in some studies.<\/jats:p>","DOI":"10.1111\/odi.14146","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T12:44:00Z","timestamp":1644065040000},"page":"1339-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Genetic and epigenetic studies in non\u2010syndromic oral clefts"],"prefix":"10.1111","volume":"28","author":[{"given":"Azeez","family":"Alade","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Radiology and Medicine College of Dentistry University of Iowa Iowa City Iowa USA"},{"name":"Iowa Institute for Oral Health Research University of Iowa Iowa City Iowa USA"},{"name":"Department of Epidemiology College of Public Health University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheed","family":"Awotoye","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Radiology and Medicine College of Dentistry University of Iowa Iowa City Iowa USA"},{"name":"Iowa Institute for Oral Health Research University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-5964","authenticated-orcid":false,"given":"Azeez","family":"Butali","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Radiology and Medicine College of Dentistry University of Iowa Iowa City Iowa USA"},{"name":"Iowa Institute for Oral Health Research University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128406"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00406"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201002721\u20100"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1826"},{"issue":"3","key":"e_1_2_16_6_1","first-page":"348","article-title":"Association of genetic variation of the transforming growth factor\u2010alpha gene with cleft lip and palate","volume":"45","author":"Ardinger H. 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