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Both agents were administered together to establish the comorbid group. All models were treated with adeno\u2010associated virus\u2010green fluorescent protein (AAV\u2010GFP) or adeno\u2010associated virus small hairpin Rgs10 (AAV\u2010sh\u2010Rgs10). In vivo expression of Rgs10 and inflammatory cytokines was analysed, along with exploration of the NF\u2010\u03baB signalling pathway in lipopolysaccharide\u2010stimulated mouse\u2010derived RAW264.7 cells, with and without treatment of small interfering RNA (siRNA; Rgs10\u2010Mus\u2010MSS245072).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the comorbidity mouse group (mice with both periodontitis and rheumatoid arthritis), inhibition of Rgs10 exacerbated periodontitis, along with upregulation of phospho\u2010RelA (pP65), tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106) expression in the NF\u2010\u03baB signalling pathway. Similarly, treatment of LPS\u2010stimulated RAW264.7 cells with siRNA resulted in the inhibition of Rgs10, along with upregulation of pP65, TNF\u2010\u03b1 and IL\u20106 expression in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inhibition of Rgs10 in mice with periodontitis and rheumatoid arthritis can promote the progression of periodontitis, indicating the potential therapeutic role of Rgs10 in this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14147","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T02:49:23Z","timestamp":1644029363000},"page":"1802-1811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of Rgs10 aggravates periodontitis with collagen\u2010induced arthritis via the nuclear factor\u2010\u03baB pathway"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-6365","authenticated-orcid":false,"given":"Wei\u2010cheng","family":"Chan","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Sichuan People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Tan","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction Department of Prosthodontics School of Medicine Tianjin Stomatological Hospital Nankai University  Tianjin People\u2019s Republic of 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