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The long non\u2010coding RNA (lncRNA) MRPL23 antisense RNA 1 (MPRL23\u2010AS1) is related to lung metastasis in SACC, but its role in anoikis resistance is unknown. After altering MPRL23\u2010AS1 expression in SACC cells, anoikis resistance was detected by calcein AM\/PI staining and annexin V\/PI flow cytometry. The apoptosis marker activated caspase\u20103 and the bcl\u20102\/bax ratio were detected by Western blotting. The relationship between MPRL23\u2010AS1 and the promoter of the potential downstream target gene p19INK4D was identified by chromatin immunoprecipitation (ChIP)\u2010PCR assay. p19INK4D expression in patient tissues was determined using qRT\u2010PCR and immunohistochemistry. The functional experiments showed that MPRL23\u2010AS1 could promote anoikis resistance in vitro. MRPL23\u2010AS1 recruited the EZH2 to the promoter region of p19INK4D, inhibited p19INK4D expression, and promoted tumor cell anoikis resistance. p19INK4D overexpression did not affect anoikis in attached cells; however, it attenuated the anoikis resistance effect of MPRL23\u2010AS1 in suspension cells. p19INK4D expression was significantly lower in SACC tissues than in normal tissues. The novel MRPL23\u2010AS1\/p19INK4D axis may be a potential SACC biomarker or therapeutic target.<\/jats:p>","DOI":"10.1111\/odi.14156","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T16:59:18Z","timestamp":1645117158000},"page":"1588-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long non\u2010coding RNA MRPL23\u2010AS1 suppresses anoikis in salivary adenoid cystic carcinoma in vitro"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-6257","authenticated-orcid":false,"given":"Yin\u2010Ran","family":"Li","sequence":"first","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Material  Beijing China"},{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Fu","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Material  Beijing China"},{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u2010Qing","family":"Song","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Material  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Material  Beijing China"},{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Yuan","family":"Ge","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Material  Beijing China"},{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.01.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010012\u20101289\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201019\u20100819"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207945"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.04.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2021_201112N1212"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.7931"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511401407"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu406"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27408"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.10.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5069"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.04.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201009\u2010113266"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.047258"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24091"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22919"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.05.047"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10887"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.10.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky822"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010632309113"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585\u2010009\u20109256\u20109"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138341"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2003.0448"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600862"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010019\u20101101\u20104"},{"issue":"1","key":"e_1_2_9_30_1","article-title":"Establishment of a human cancer cell line from adenoid cystic carcinoma of the minor salivary gland","volume":"25","author":"Li S. 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