{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:29:17Z","timestamp":1783355357137,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Depth of invasion (DOI) is the most important predictor for lymph node metastasis in early\u2010stage oral cancer. This study aims to investigate the effects of the different classifications of AJCC 7th and 8th on predicting lymph node metastasis and the optimal cutoff point for DOI predicting the lymph node metastasis in patients with tongue squamous cell carcinoma (TSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We performed a retrospective study in 208\u00a0TSCC patients in early T stage without clinical or radiological signs of lymph node metastasis. Those patients were treated with elective neck dissection (END) between April 2019 and December 2020. And the relation between DOI and lymph node metastasis was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Metastases were found in 58 of 208 patients (27.88%). Of those 58 patients, the mean DOI was 8.311\u00a0mm compared to 5.425\u00a0mm in patients without metastases (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). The receiver operating characteristic curve (ROC curve) showed an area under the curve of 0.7066 with the most optimal cutoff point on a DOI of 4.050\u00a0mm (sensitivity 86.21%, specificity 52%). Linear regression analysis (1\u00a0mm\u00a0\u2264\u00a0DOI\u00a0\u22646\u00a0mm) revealed that a DOI\u00a0\u2265\u00a03.211\u00a0mm predicated an incidence of occult lymph node metastasis greater than 20%. Regional metastases were found in 12.82% of patients with DOI\u00a0\u2264\u00a04.0\u00a0mm. Within the entire cohort, 60 cases (28.85%) got upgraded with respect to T stage. No tumor underwent downstaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 8th edition provides better lymph node metastasis prediction for TSCC than the 7th. And DOI is a poor predictor for regional metastasis in patients with early T stage clinically node\u2010negative TSCC. END in patients with early\u2010stage TSCC should be performed in patients with DOI\u00a0\u2265\u00a03.211\u00a0mm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14178","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T07:48:40Z","timestamp":1646466520000},"page":"1542-1549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative study on classifications of AJCC 8th and 7th in the patients with tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Shun","family":"Yu","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-8564","authenticated-orcid":false,"given":"Zi\u2010Li","family":"Yu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University  Wuhan China"},{"name":"Department of Oral Maxillofacial\u2010Head Neck Oncology School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Wu","family":"Ye","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-5567","authenticated-orcid":false,"given":"Jun","family":"Jia","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University  Wuhan China"},{"name":"Department of Oral Maxillofacial\u2010Head Neck Oncology School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010015\u20101758\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.10.009"},{"key":"e_1_2_9_4_1","volume-title":"AJCC Cancer Staging Manual","author":"American Joint Committee on Cancer (AJCC)","year":"2018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.09.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24724"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006205.pub4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100347(199701)19:1<14:AID\u2010HED3>3.0.CO;2\u2010Y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13194"},{"key":"e_1_2_9_10_1","volume-title":"Head and\u2010neck\u2010cancers","author":"Cancer Research UK","year":"2018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27205"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.03.243"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010006\u20100088\u20104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25665"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202632"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2020.06.037"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750061615"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27872"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26229"},{"key":"e_1_2_9_22_1","volume-title":"Malignant tumours of the mobile tongue","author":"Gosselin B. 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