{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:11:58Z","timestamp":1790273518658,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071150"],"award-info":[{"award-number":["82071150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of intermittent parathyroid hormone on cementoblast\u2010mediated periodontal repair in the context of orthodontic\u2010induced root resorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The rat model of orthodontic\u2010induced root resorption was established. Sixty rats were randomly allocated into the experiment group (n\u00a0=\u00a030) and the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030), either receiving a daily subcutaneous injection of recombinant human PTH or placebo vehicle. Enzyme\u2010linked immunosorbent assay, Micro\u2010computed tomography, hematoxylin and eosin staining, and immunohistochemistry staining were performed to detect the periodontal repair. In vitro, OCCM\u201030 cells were exposed to intermittent PTH (incubated with PTH for the first 6\u00a0h in each 24\u2010h cycle). After three cycles, flow cytometry assay, alkaline phosphatase staining, and Alizarin red staining were performed. Quantitative real\u2010time polymerase chain reaction and Western blotting were employed to further determine the effects of intermittent PTH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intermittent PTH\u2010responsive repair enhancement was detected with the expression of bone sialoprotein, osteocalcin, collagen\u20101, and alkaline phosphatase significantly upregulated. Increased expressions of cementoblastic proteins were positively correlated to cycles of PTH administration. The proportion of cementoblasts in S and G2\/M phases was increased; namely, intermittent PTH promoted cementoblast cell proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intermittent parathyroid hormone administration promotes cementoblast\u2010mediated cementogenesis during periodontal repair in a time\u2010dependent manner.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14180","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T08:50:50Z","timestamp":1646643050000},"page":"1747-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of intermittent parathyroid hormone on cementoblast\u2010mediated periodontal repair"],"prefix":"10.1111","volume":"29","author":[{"given":"Ye","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Nanjing Stomatological Hospital Medical school of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"School of Stomatology Institute of Dental Research and Department of Orthodontics Beijing Stomatological Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1918-1847","authenticated-orcid":false,"given":"Jianwei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"28","article-title":"Osteogenic differentiation potential and quantification of fresh and cryopreserved dental follicular stem cells\u2010an in vitro analysis","volume":"17","author":"AlHindi M.","year":"2021","journal-title":"The Journal of Stem Cells and Regenerative Medicine"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005361"},{"key":"e_1_2_10_4_1","first-page":"499","article-title":"Teriparatide in the management of osteoporosis","volume":"2","author":"Bodenner D.","year":"2007","journal-title":"Clinical Interventions in Aging"},{"key":"e_1_2_10_5_1","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. 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