{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:44:28Z","timestamp":1791632668446,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This systematic review compared children's primary dentition caries experience for those with cleft lip and\/or palate (CL\/P) and without. Four databases were searched without date restriction for; cross\u2010sectional studies comparing caries experience for children with CL\/P to those without. Screening, data extraction and risk assessment were carried out independently (in duplicate). Meta\u2010analyses used a random\u2010effects model. Twenty studies (21 reports) fitting the inclusion criteria comprised 4647 children in primary dentition from 12 countries. For dmft (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03016 children; 15 groups), CL\/P mean\u00a0=\u00a03.2; standard deviation\u00a0=\u00a02.22 and no CL\/P mean dmft\u00a0=\u00a02.5; sd 1.53. For dmfs (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01095 children; 6 groups), CL\/P mean\u00a0=\u00a04; sd\u00a0=\u00a03.5 and no CL\/P mean\u00a0=\u00a03; sd\u00a0=\u00a02.8. For % caries experience (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01094 children; 7 groups), CL\/P mean\u00a0=\u00a065%; sd\u00a0=\u00a020.8 and no CL\/P mean\u00a0=\u00a052%; sd\u00a0=\u00a028.1. Meta\u2010analysis showed higher caries experience in children with CL\/P, standardised mean difference\u00a0=\u00a00.46; 95% CI\u00a0=\u00a00.15, 0.77. Studies' risk of bias was high (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07), medium (\n                    <jats:italic>n<\/jats:italic>\n                    \u221210) and low (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03). Children with CL\/P had higher caries experience compared to those without CLP.\n                  <\/jats:p>","DOI":"10.1111\/odi.14183","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T19:45:19Z","timestamp":1646855119000},"page":"1400-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Caries in children with and without orofacial clefting: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Rebecca E.","family":"Grewcock","sequence":"first","affiliation":[{"name":"Dental Hospital and School University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P. T.","family":"Innes","sequence":"additional","affiliation":[{"name":"School of Dentistry Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Mossey","sequence":"additional","affiliation":[{"name":"Dental Hospital and School University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0005-3044","authenticated-orcid":false,"given":"Mark D.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Dental Hospital and School University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300218"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000349911"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620944758"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010018\u20100640\u20101"},{"key":"e_1_2_12_6_1","first-page":"897","article-title":"Studies on caries incidence in patients with clefts","volume":"22","author":"Bethmann W.","year":"1967","journal-title":"Deutsche Zahnarztliche Zeitschrift"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"147","article-title":"Zum Kariesbefall bei Spalttr\u00e4gern, unter besonderer Ber\u00fccksichtigung der Spaltformen [On caries incidence in patients with clefts, with special reference to the cleft types]","volume":"78","author":"Bethmann W.","year":"1968","journal-title":"SSO Schweiz Monatsschr Zahnheilkd"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100722.1996.tb00135.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000262366"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262754"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620980206"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947\u20102714.134371"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002487"},{"issue":"3","key":"e_1_2_12_14_1","first-page":"233","article-title":"Caries, gingivitis, and dental abnormalities in preschool children with cleft lip and\/or palate","volume":"26","author":"Dahllof G.","year":"1989","journal-title":"The Cleft Palate Journal"},{"issue":"1","key":"e_1_2_12_15_1","first-page":"37","article-title":"Epidemiological survey of tooth decay in young children with cleft lip and palate","volume":"21","author":"Halitchi L.\u2010G.","year":"2017","journal-title":"International Journal of Medical Dentistry"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517696457"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20105037.2009.00426.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875\u2010595x.2001.tb00825.x"},{"key":"e_1_2_12_19_1","first-page":"134","article-title":"Caries statistical studies in 1198 children with cleft lips and cleft palates","volume":"55","author":"Hochstein U.","year":"1970","journal-title":"Deutsche Zahn Mund und Kieferheilkunde mit Zentralblatt fur die Gesamte"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517709961"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010015\u20101455"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1597\/11-133"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1597\/12\u2010106"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12195"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545\u20101569_1999_036_0522_cpabfp_2.3.co_2"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2018.05.021"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545\u20101569_2000_037_0447_dhiaca_2.0.co_2"},{"key":"e_1_2_12_28_1","first-page":"422","article-title":"Dental caries status in children with and without cleft lip and palate: A case control study","volume":"11","author":"Malay K. 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