{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:47:22Z","timestamp":1790970442546,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the particular craniofacial characteristics of Van der Woude syndrome(VWS) patients compared to patients with a non\u2010syndromic cleft (CG1) and to a malocclusive healthy population (CG2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      Retrospective case\u2010control study. A sample of 110\u00a0matched\u2010patients was recruited (VWS (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07), CG1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049), CG2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049)). Subsequently, 37\u00a0radiometric variables were analysed and the dental\u2010skeletal ages were determined. The intra\/inter\u2010observer method errors were quantified. Descriptive statistics were computed, and different inferential analysis tests were used depending on the normality of the data (Chi\u2010square test, Fisher's exact test, paired Student's\n                      <jats:italic>T<\/jats:italic>\n                      \u2010test, Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt; 0.05). Pairwise comparisons were corrected by Bonferroni's criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VW\u2010patients presented specific craniofacial characteristics and morphology. A marked tendency to the vertical growth pattern was found in VW\u2010patients compared to CG1\u2010CG2 (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001); at the sagittal level, skeletal class II caused by mandibular retrognathism, with a greatly increased ANB angle compared to CG1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042). Dental analysis showed that the lower incisor was more retruded and retroclined (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05 in all cases) and the interincisal angulation was increased (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001 (CG2)). At the profile level, an open nasolabial angle (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.040; CG1) and a more protruding lower lip with respect to the Sn\u2010Pg plane (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.040 (CG1);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044 (CG2)) were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VW\u2010patients present particular characteristics in the facial skeletal structures. There is a critical necessity to increase the evidence regarding specific clinical features and orofacial pathology of rare diseases such as VWS, which will help to these minorities to gain access in the future to a better quality of care with precise treatment and diagnostic necessities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14187","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T15:13:06Z","timestamp":1647270786000},"page":"1680-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Craniofacial characteristics in Van der Woude syndrome"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8410-8742","authenticated-orcid":false,"given":"Blanca","family":"Est\u00e9vez\u2010Arroyo","sequence":"first","affiliation":[{"name":"Department of Orthodontics College of Dentistry University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"G\u00f3mez\u2010Mendo","sequence":"additional","affiliation":[{"name":"Maxillofacial and Stomatology Department Virgen Macarena University Hospital of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Romero\u2010Maroto","sequence":"additional","affiliation":[{"name":"Head of the Orthodontic Department Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-0934","authenticated-orcid":false,"given":"Enrique","family":"Solano\u2010Reina","sequence":"additional","affiliation":[{"name":"Department of Orthodontics College of Dentistry University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-1612","authenticated-orcid":false,"given":"Alejandro","family":"Iglesias\u2010Linares","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.23804\/ejpd.2018.19.01.13"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"316","article-title":"An Improved Version of the Cervical Vertebral Maturation (CVM) Method for the Assessment of Mandibular Growth","volume":"72","author":"Baccetti T.","year":"2002","journal-title":"Angle Orthodontist"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109416(71)90116\u20103"},{"key":"e_1_2_10_5_1","first-page":"162","article-title":"Cephalometric comparisons on the cranial base and face in individuals with isolated clefts of the palate","volume":"11","author":"Bishara S.","year":"1974","journal-title":"Cleft Palate\u2010Craniofacial Journal"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109416(55)90005\u20101"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"99","article-title":"Genetic epidemiology and control of genetic expression in van der Woude syndrome","volume":"6","author":"Burdick A. 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