{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:46Z","timestamp":1772160826971,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the present study was to explore the clinical characteristics of BP180NC16a autoantibody\u2010positive mucous membrane pemphigoid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and methods<\/jats:title>\n                    <jats:p>Data from 22 patients were collected by retrospective chart review. For the detection of BP180NC16a autoantibody, a commercially available enzyme\u2010linked immunosorbent assay or chemiluminescent enzyme immunoassay kit was used. The patients were classified into the following clinical phenotypes: low\u2010risk patients who had lesions only in the oral mucosa or in the oral mucosa and skin and high\u2010risk patients who had lesions in the oral mucosa and any of the following sites: the eyes, upper respiratory tract, or esophagus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven of the 22 patients (50%) were BP180NC16a\u2010positive at the time of diagnosis. All the positive patients were in the low\u2010risk group. There was a significant difference in the incidence of low\u2010risk mucous membrane pemphigoid between BP180NC16a autoantibody\u2010positive and BP180NC16a autoantibody\n                      <jats:bold>\u2010<\/jats:bold>\n                      negative patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). Patients' age, disease duration, and oral disease activity scores were not significantly different between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BP180NC16a reactivity was associated with the clinical phenotype characterized by only oral mucosal lesions or combined oral mucosal and skin lesions. BP180NC16a autoantibody might be useful as a serum marker to predict low\u2010risk mucous membrane pemphigoid.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14198","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T05:03:21Z","timestamp":1648184601000},"page":"2224-2229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["BP180NC16a autoantibody positivity may predict low\u2010risk mucous membrane pemphigoid"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-2029","authenticated-orcid":false,"given":"Hiroyasu","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Oral Diagnostics School of Dentistry at Matsudo Nihon University  Matsudo 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