{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:15:37Z","timestamp":1761808537092,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess whether microcephaly is a risk factor for alterations in the chronology and sequence of tooth eruption and for developmental defects of enamel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Matherials and Methods<\/jats:title><jats:p>In this case\u2010control study, 81 children aged 30\u201336\u00a0months, including 40 normoreactive children and 41 with microcephaly, were submitted to oral clinical examination to determine the frequency of alterations in the chronology and sequence of tooth eruption and developmental enamel defects. The sample was matched for sex and age (1:1) and allocated to the case (presence of dental alterations) and control (absence of dental alterations) groups. Gestational age, birthweight and socioeconomic characteristics were also analyzed. Chi\u2010square test and Fisher's exact test were applied (<jats:italic>\u03b1<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microcephaly was significantly associated with delayed tooth eruption, alterations in the sequence of tooth eruption, and defects in dental enamel (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Low birthweight also showed a significant association with this alterations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005) and prematurity was associated with defects in enamel development (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microcephaly is a risk factor for alterations in the tooth eruption process and enamel formation in primary teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14199","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T09:02:21Z","timestamp":1648198941000},"page":"2265-2271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microcephaly as a risk factor for dental alterations: A case\u2010control study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-226X","authenticated-orcid":false,"given":"Patr\u00edcia N\u00f3brega","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Dentistry School of Dentistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelita Duarte","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Aguiar","family":"do Amaral","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivia Maria Rodrigues","family":"Arrais","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenio Costa de","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"411","article-title":"Commission on oral health research and epidemiology. 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