{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:47:32Z","timestamp":1790189252216,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is a paradoxical effect associated with bone\u2010modifying agents (BMAs) and other drugs. Currently, no valuable diagnostic or prognosis biomarkers exist. The goal of this research was to study MRONJ\u2010related salivary proteome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This case\u2013control aimed to study salivary proteome in MRONJ versus control groups (i) formed from BMAs consumers and (ii) healthy individuals to unravel biomarkers. Thirty\u2010eight samples of unstimulated whole saliva (18\u00a0MRONJ patients, 10 BMA consumers, and 10\u00a0healthy controls) were collected. Proteomic analysis by SWATH\u2010MS coupled with bioinformatics analysis was executed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 586 proteins were identified, 175 proteins showed significant differences among MRONJ versus controls. SWATH\u2010MS revealed differentially expressed proteins among three groups, which have never been isolated. These proteins had distinct roles including cell envelope organization, positive regulation of vesicle fusion, positive regulation of receptor binding, or regulation of low\u2010density lipoprotein particle clearance. Integrative analysis prioritized 3 proteins (MMP9, AACT, and HBD). Under receiver\u2010operating characteristic analysis, this panel discriminated MRONJ with a sensitivity of 90% and a specificity of 78.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings may inform a novel biomarker panel for MRONJ prediction or diagnosis. Nonetheless, further research is needed to validate this panel.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14201","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T11:54:10Z","timestamp":1649073250000},"page":"2117-2129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative proteomics in medication\u2010related osteonecrosis of the jaw: A proof\u2010of\u2010concept study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-4703","authenticated-orcid":false,"given":"Alejandro I.","family":"Lorenzo\u2010Pouso","sequence":"first","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana B.","family":"Bravo","sequence":"additional","affiliation":[{"name":"Proteomic Unit Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Carballo","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Sciences University of Vigo\u2010Ourense Campus  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Pilar","family":"Chantada\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Proteomic Unit Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Bag\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Stomatology and Maxillofacial Surgery University General Hospital of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Bag\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Stomatology and Maxillofacial Surgery University General Hospital of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-9908","authenticated-orcid":false,"given":"Cintia M.","family":"Chamorro\u2010Petronacci","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Conde\u2010Amboage","sequence":"additional","affiliation":[{"name":"Models of Optimization, Decision, Statistics and Applications Research Group (MODESTYA). Department of Statistics, Mathematical Analysis and Optimization University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"L\u00f3pez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Translational Medical Oncology Group (Oncomet) Health Research Institute of Santiago (IDIS), University Hospital Complex of Santiago de Compostela (SERGAS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-9868","authenticated-orcid":false,"given":"Mario","family":"P\u00e9rez\u2010Say\u00e1ns","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela 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