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Therefore, clarifying the correlation between oral microbes and metabolites is important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study tested with 16S rRNA gene amplicon and shotgun metagenomic sequencing of oral microorganisms and oral malodor tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were different of the microbial taxa between the low and high H<jats:sub>2<\/jats:sub>S groups. And in the high H<jats:sub>2<\/jats:sub>S group, most of the enriched taxa were genera which abundance was correlated with H<jats:sub>2<\/jats:sub>S concentration. <jats:italic>Fusobacterium periodonticum<\/jats:italic> and <jats:italic>Prevotella nanceiensis<\/jats:italic> were significantly different in coverage breadth and depth and in LPS biosynthesis contributions between the two groups. The contribution of <jats:italic>F<\/jats:italic>. <jats:italic>periodonticum<\/jats:italic> to sulfur metabolism was significantly different between the two groups, and the relative <jats:italic>F<\/jats:italic>. <jats:italic>periodonticum<\/jats:italic> abundance was higher in the high H<jats:sub>2<\/jats:sub>S group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The H<jats:sub>2<\/jats:sub>S content is significantly associated with the oral cavity microorganism composition and abundance. Most microorganisms enriched in people with high H<jats:sub>2<\/jats:sub>S levels are associated with oral diseases such as caries and periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14211","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T04:19:13Z","timestamp":1649996353000},"page":"2283-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlation between the salivary microbiology and H<sub>2<\/sub>S concentration of the oral cavity"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-1198","authenticated-orcid":false,"given":"Jiarui","family":"Jiang","sequence":"first","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-1091","authenticated-orcid":false,"given":"Yufen","family":"Huang","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qili","family":"Mi","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Li","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silong","family":"Sun","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-7566","authenticated-orcid":false,"given":"Baokun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-4657","authenticated-orcid":false,"given":"Qian","family":"Gao","sequence":"additional","affiliation":[{"name":"Joint Institute of Tobacco and Health Yunnan Academy of Tobacco Science  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875\u2010595X.2002.tb00927.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010017\u20100967\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v7.28166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302X.1993.tb00541.x"},{"key":"e_1_2_10_6_1","first-page":"7","article-title":"Overview of research methods and applications of metagenomics","volume":"34","author":"Changwen P.","year":"2009","journal-title":"Biology Teaching"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0510\u2010335"},{"key":"e_1_2_10_8_1","first-page":"799","article-title":"CNGBdb: China National GeneBank DataBase","volume":"42","author":"Chen F. 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