{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T18:05:24Z","timestamp":1781028324305,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To obtain the relative volume by measuring the tongue volume and the lesion volume, and further explore its relationship with the prognosis of patients, hoping to supplement the TNM staging with a new index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ITK\u2010SANP software was used to outline the patients\u2019 MRI. After MRI reconstruction and measurement, slicer software was used to estimate tumor volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 64 patients with tongue cancer who met the inclusion criteria were included in the study. The estimated tumor volume after MRI reconstruction revealed a significant and robust correlation with tumor stage (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05, Rs\u00a0=\u00a00.6207) and a substantial and medium correlation with early lymph node metastasis (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05, Rs\u00a0=\u00a00.4873).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We classified tongue cancer into three grades based on tumor volume (Stage I, tumors smaller than 1500\u00a0mm\u00b3; Stage II, tumors 1500\u20139000\u00a0mm\u00b3; and Stage III, tumors larger than 9000\u00a0mm\u00b3), and such grading could be used as a reference for tumor staging, lymph node metastasis, and patient prognosis to a certain extent.<\/jats:p>\n                  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