{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:42:05Z","timestamp":1773697325163,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100955"],"award-info":[{"award-number":["82100955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The mechanisms of regional acceleratory phenomenon (RAP) induced by orthognathic osteotomy are unclear. It was not known if locally hypoxic microenvironment changes were involved in this phenomenon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hypoxia\u2010induced factor\u20101\u03b1 knockout mice harboring Cathepsin K (CTSK) Cre were used to investigate the effect of hypoxia\u2010driven osteoclasts on alveolar bone remodeling. RAW264.7 cells were induced by CoCl\n                      <jats:sub>2<\/jats:sub>\n                      to observe the effects of dendritic cell\u2010specific transmembrane protein (DC\u2010STAMP) on the fusion and differentiation of osteoclasts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found mandibular osteotomy of C57\u00a0mice induced active alveolar osteoclasts and increased hypoxia\u2010induced factor\u20101\u03b1 (HIF\u20101\u03b1) positive staining areas. Alveolar bone density of the 10\u2010week\u2010old HIF\u20101\u03b1 conditional knockout (CKO) mouse was increased at 10 and 14\u00a0days after bilateral mandibular osteotomy. Moreover, decreased numbers of osteoclasts and matrix metalloproteinase 9 (MMP\u20109)\u2010positive cells were observed on the surface of bone resorption lacunae in the CKO group. HIF\u20101\u03b1 could increase the expression level of DC\u2010STAMP to enhance osteoclastogenesis and cell fusion in active RAW264.7 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data considered hypoxia\u2010driven osteoclasts resorption to be an adaptive mechanism to permit alveolar bone loss after bilateral mandibular osteotomy of mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14215","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:03:31Z","timestamp":1650510211000},"page":"2139-2153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypoxia\u2010induced factor 1\u03b1 promotes osteotomy\u2010induced regional acceleratory phenomenon via DC\u2010STAMP mediated membrane 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